Results 141 to 150 of about 731,022 (305)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Event structure of problem situations
Вестник Самарского государственного технического университета. Серия: Психолого-педагогические науки, 2018 In the paper the notion of “situation” is analyzed in linguistic and psychological context. The review of approaches to the definition of situations is presented.
Viсtoria V. Dobrova, Helen V. Butina
doaj
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
The interface of lexical semantics and conceptual structure deverbal and denominal nominalizations
, 2013 Nominalizations can refer to events, instances of events or participants in an event. The particular reference is determined by the lexical semantics of the base and the suffix, and by the conceptual structure of the base. The comparison between deverbal
Heusinger, Klaus von
core
Memory Performance and Event Structure
, 2019 Dividing information into more than one event has been shown to enhance or impair memory performance in different studies. Recent findings suggested that the number of events at both encoding and testing work together to influence prospective memory ...
Andrea E. O'Rear (17603640)
core +1 more source
Event Structures for Mixed Choice.
, 2019 In the context of models with mixed nondeterministic and probabilistic choice, we present a concurrent model based on partial orders, more precisely Winskel’s event structures. We study its relationship with the interleaving-based model of Segala’s probabilistic automata. Lastly, we use this model to give a truly concurrent semantics to an extension of
openaire +4 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Event Structure and Adverbial Modification
, 1999 We argue that event structure as a level of semantic representation provides a suitable place to account for the semantic properties of adverbs like slowly, quickly and almost. These adverbs are event modifiers. We also show that causal interpretation in
Ito Toshinori
core