Results 91 to 100 of about 5,530,700 (284)

A Graphical Tool for Event Refinement Structures in Event-B [PDF]

, 2016
The Event Refinement Structures ERS approach provides a graphical extension of the Event-B formal method to represent event decomposition and control-flow explicitly. In this paper we present an improved version of the ERS plug-in, which provides a graphical environment for the ERS approach within the Event-B tool, Rodin.
Dana Dghaym, Matheus Garay Trindade, Michael J. Butler, Asieh Salehi Fathabadi   +3 more
openaire   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A Key Event Path Analysis Approach for Integrated Systems

Modelling and Simulation in Engineering, 2012
By studying the key event paths of probabilistic event structure graphs (PESGs), a key event path analysis approach for integrated system models is proposed.
Jingjing Liao
doaj   +1 more source

Derived nominals from the nominal perspective

Anuario del Seminario de Filología Vasca "Julio de Urquijo", 2009
Derived Nominals are considered to be the last stage in the nominalization scale. This scale includes a continuum of structures with both nominal and verbal characteristics, and derived nominals are the most nouny in it.
Itziar San Martin
doaj   +1 more source

Contextualizing phenomenology in event management research: Deciphering the meaning of event experiences [PDF]

, 2013
Purpose - Although the core phenomenon of events is the experiences and the meanings attached to them, there is limited management research on the experiential, existential and ontological dimensions of events.
Vassilios Ziakas, Nikolaos Boukas, Ziakas, Vassilios, Boukas, Nikolaos, Boukas, N, Ziakas, V   +5 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Event Type and Relationship Extraction Based on Dependent Syntactic Semantic Augmented Graph Networks

IEEE Access
In natural language processing, tasks like trigger word extraction, event type recognition, and event relation extraction are essential. These tasks facilitate the extraction of salient information through detailed textual analysis, enhancing the ...
Min Zuo, Zexi Song, Qingchuan Zhang, Yueheng Liu, Di Wu, Yuanyuan Cai   +5 more
doaj   +1 more source

Approaches for fatigue design of tubular structures

, 2008
This paper summarizes the methods that are currently most used for the design of tubular structures subjected to fatigue loading. The methods that are mostly used for the fatigue design of tubular structures are the classification method, the hot spot ...
Chen, Y. Y., Zhao, Xiao-Ling, Mashiri, Fidelis R., Shen, Z. Y., Dong, Pingsha, Zhao, Xian-zhong   +5 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source