Results 211 to 220 of about 2,115,111 (294)

Efficient algorithms for simulating sequences along a phylogenetic tree. [PDF]

Bioinformatics
Wygoda E, Moshe A, Serok N, Dotan E, Ecker N, Jabareen N, Israeli O, Pe'er I, Pupko T.   +8 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Analyzing Fault Reactivation Behavior Using InSAR, Stress Inversion, and Field Observations During the 2025 Sındırgı Earthquake Sequence, Simav Fault Zone, Western Türkiye. [PDF]

Sensors (Basel)
Kutoğlu ŞH, Softa M, Akgün E, Nas M, Topal S.   +4 more
europepmc   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Addressing the data imbalance issue in machine learning modeling of rare and disruptive outage events. [PDF]

Sci Rep
Azizi M, Zhang X, Yasenpoor T, Cerrai D, Song D, Anagnostou E.   +5 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Structure-Based Design of Reversible, Quinoline-2(1<i>H</i>)‑one Inhibitors of Serine- and Metallo-Carbapenemases. [PDF]

ACS Omega
Jacobs LMC, Jaishankar P, Zheng J, Hantz ER, Lee I, Narramneni K, Poore N, Torres N, Jackson JK, Williams O, Darch SE, Shaw LN, Chen Y, Renslo AR.   +13 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Aging and memory for temporal order in naturalistic events. [PDF]

Psychol Aging
Ding Y, Alperin DR, Zacks JM.
europepmc   +1 more source