Results 131 to 140 of about 1,954,568 (309)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Everyday experience and community development practice [PDF]
, 2015 This article explores the potential to apply what is generally known as ‘theories of everyday life’ and psychogeography to understanding how the experience of place affects individuals concept of self and their position within the world.
Beck, Dave, Purcell, Rod
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Complexity in daily life – a 3D-visualization showing activity patterns in their contexts [PDF]
This article attacks the difficulties to make well informed empirically grounded descriptions and analyses of everyday life activity patterns. At a first glance, everyday life seems to be very simple and everybody has experiences from it, but when we try
Kajsa Ellegård, Matthew Cooper
core
Water Connection: Everyday Religion and Environments in Kathmandu Valley [PDF]
, 2016 This case study aims to explore the relationship between ‘everyday religion’ and prospects for urban sustainability in the context of on-going changes -in Kathmandu.
Tamang, Mukta S
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The Structures of Everyday Life [PDF]
, 1985 This note descends from a talk I gave at the AI Lab's Revolving Seminar series in November 1984. I offer it as an informal introduction to some work I've been doing over the last year on common sense reasoning. Four themes wander in and out.
Agre, Philip E.
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
The Birth Control Divide : U. S. Press Coverage of Contraception, 1873-2013 [PDF]
, 2016 For more than 140 years, religious, medical, legislative, and legal institutions have contested the issue of contraception. In this conversation, predominantly male voices have attached reproductive rights to tangential moral and political matters ...
Garner, Ana C., Michel, Angela
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source