Results 111 to 120 of about 7,148,473 (289)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
"The Tools for Everyday Life" is a collection of products designed and made by the community of design practice that exists around the Designers in Residence scheme at Northumbria University.
Whittingham, Rickard +2 more
core
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Healthism and the Medicalization of Everyday Life
International Journal of Health Services, 1980 This article considers some implications of the new health consciousness and movements—holistic health and self-care—for the definition of and solution to problems related to “health.” Healthism represents a particular way of viewing the health problem, and is characteristic of the new health consciousness and movements.
openaire +3 more sources
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Making Sense of Everyday Life by Susie Scott
, 2011 Scott, Susie. Making Sense of Everyday Life.
Mason, Andrew
core
Living With Paradoxes: Victims of Sexual Violence in Germany and the Conduct of Everyday Life [PDF]
, 2009 [eng] The thesis describes the everyday life of victims of sexual violence in Germany, based upon the qualitative study of in-depth interviews. By means of the grounded analysis of their action system of practical coping with life on a daily basis - the ...
Kappler, Karolin Eva
core +1 more source