Results 241 to 250 of about 3,238,711 (292)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

The Role of Big Data in Developing Innovative Predictive Learning Models for Neglected Tropical Diseases within the New Generation of the Evidence-Based Medicine Pyramid. [PDF]

Infez Med
Vidal-Durango JV, Galván-Barrios J, Reyes-Duque JD, Lozada-Martinez ID.   +3 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

The state of mechanistic research in the evidence-based medicine era: A sandwalk between triangulation and hierarchies. [PDF]

Exp Physiol
Berg RMG, Durrer CG, Friis JKBO, Ried-Larsen M.   +3 more
europepmc   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

An Exploration of Mainstreaming Acupuncture by Employing Evidence-Based Medicine Teaching in Acupuncture Education-A Needs Assessment Study. [PDF]

Med Acupunct
Li D, Karp K.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Investigating the knowledge attitude and practice of evidence based medicine education in Sudanese medical students: a cross sectional study. [PDF]

BMC Med Educ
Amin MHJ, Awad MH, Mohamed Ginawi ES, Mohammed ASK, Noureldaiem Ibrahim EHE, Yassen OYM, Elomeiri LESMA, Hakim Hussain AHMA, Eltahir TA, Mohmmed FSAA, Wedatalla RAE, Awad KH, Mahgoub RKE, Karar AMA, Saeed AYM, Mohamed AEA, Mohamed Ginawi RS, Sidar FMK, Saifalsorori RRA, Osman OIA, Nouri MAI, Mohamed MAA, Ibrahim NBM, Mohamed MMM, Mohamed AEAB, MohamedAhmed FMA, Hassan MRM, Mohamed SAA, Bashar Hadi HE, Gandour HMNG, Ahmed NAF, Ahmed NME, Osman MMAA, Elhadi SEI.   +33 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Analysis of factors associated with substandard nutrition in critically ill patients and the effect of applying enteral nutrition nursing model based on evidence-based medicine: A retrospective observational study. [PDF]

Medicine (Baltimore)
Wang J, Wang J, Ye X, Lu Q, Liu Y.
europepmc   +1 more source