Results 41 to 50 of about 4,688,320 (340)
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Rationalism, Empiricism, and Evidence-Based Medicine: A Call for a New Galenic Synthesis [PDF]
, 2018 Thirty years after the rise of the evidence-based medicine (EBM) movement, formal training in philosophy remains poorly represented among medical students and their educators.
Webb, William
core +2 more sources
Journal of the Royal Society of Medicine, 2008 Duncan Neuhauser, Mireya Diaz and Iain Chalmers (JRSM 2008;101:381–383) are puzzled that one of the great pioneers of clinical trials, Russell LaFayette Cecil, failed to include a chapter on trial methodology when he went on to edit his best-selling Textbook of Medicine – but perhaps they are being diplomatic.1 If Cecil thought most doctors did not ...
openaire +4 more sources
Cardiovascular TherapeuticsConclusion: SMS used alone or combined with WM may have potential effectiveness on symptom alleviation, ECG recovery rate, myocardial injury markers, and cardiac function, but the effectiveness is uncertain due to the low quality and absence of placebo ...
Bing-rui Zhang +8 more
doaj +1 more source
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Evidence-based medicine : an overview [PDF]
, 1998 Evidence-Based Medicine (EBM) is about combining the best clinical expertise with the best available clinical information in the literature. At face value, this statement may seem simplistic, but closer scrutiny will lead to a reappraisal.
Tilney, Myra Kay
core
PROSPERO's systematic review protocols of traditional Chinese medicine for COVID-19: An overview
Integrative Medicine Research, 2021 Background: A large number of protocols for Systematic Reviews (SR) of Traditional Chinese Medicine (TCM) for coronavirus disease 2019 (COVID-19) have been registered in the International Prospective Register of Systematic Reviews (PROSPERO).
Haiyin Hu +6 more
doaj
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Chinese Medicine, 2017 Background Both cupping therapy and acupuncture have been used in China for a long time, and their target indications are pain-related conditions. There is no systematic review comparing the effectiveness of these two therapies. Objectives To compare the
Ya-Jing Zhang +6 more
doaj +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source