Results 61 to 70 of about 4,688,320 (340)

Emerging photodynamic/sonodynamic therapies for urological cancers: progress and challenges

Journal of Nanobiotechnology, 2022
Photodynamic therapy (PDT), and sonodynamic therapy (SDT) that developed from PDT, have been studied for decades to treat solid tumors. Compared with other deep tumors, the accessibility of urological tumors (e.g., bladder tumor and prostate tumor) makes
Xiao Hu, Yu-Sen Zhang, Yi-Chao Liu, Na Wang, Xian-Tao Zeng, Ling-Ling Zhang   +5 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Does the Removal of Textbook Reading from Emergency Medicine Resident Education Negatively Affect In-Service Scores? [PDF]

, 2020
Introduction: In-service exam scores are used by residency programs as a marker for progress and success on board exams. Conference curriculum helps residents prepare for these exams.
Bove, Joseph, Hochman, Steven, Ju, Christine   +2 more
core  

The compass, crow's nest and ship of medicine in the sea of uncertainties [PDF]

, 2009
Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Discipline of Emergency Medicine and Evidence-Based MedicineAssociação Paulista de MedicinaUNIFESP, EPM, Discipline of Emergency Medicine and Evidence-Based ...
Atallah, Álvaro Nagib
core   +2 more sources

Research Collaboration and Outcome Measures of Interventional Clinical Trial Protocols for COVID-19 in China

Frontiers in Public Health, 2020
Background: Research collaboration of registered clinical trials for Coronavirus Disease 2019 (COVID-19) remains unclear. This study aimed to analyze research collaboration and distribution of outcome measures in registered interventional clinical trials
Ya Gao, Kelu Yang, Ming Liu, Yamin Chen, Shuzhen Shi, Fengwen Yang, Jinhui Tian, Jinhui Tian, Jinhui Tian   +8 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

How are "teaching the teachers" courses in evidence based medicine evaluated? A systematic review [PDF]

, 2010
Background Teaching of evidence-based medicine (EBM) has become widespread in medical education. Teaching the teachers (TTT) courses address the increased teaching demand and the need to improve effectiveness of EBM teaching.
A Coomarasamy, Andrea R Horvath, Anna Kaleta, Ben WJ Mol, Berit Meyerrose, Bernard Burnand, CA Cartwright, Chantal Arditi, DH Naftulin, Elżbieta Gabryś, GD Fenstermacher, Gee Harry, Gemma Barnfield, Gianni Zanrei, I Bates, J Kouhpayehzadeh, Jacek Walczak, JJ Deeks, JL Dorsch, Katja Suter, Katrien Oude Rengerink, Khalid S Khan, Krzysztof Kloc, KS Khan, L Darling-Hammond, L Fritsche, L Hutchinson, M Wilkes, MK Aiyer, ML Green, O Ribeiro, R Kulier, R Yousefi-Nooraie, Regina Kunz, S Thangaratinam, SF Coppus, Shakila Thangaratinam, Susanne Weinbrenner, T Shaneyfelt, Theodoros N Arvanitis   +39 more
core   +9 more sources

Evidence-based occupational health and safety interventions: a comprehensive overview of reviews

BMJ Open, 2019
Objectives Occupational injuries and diseases are a huge public health problem and cause extensive suffering and loss of productivity. Nevertheless, many occupational health and safety (OHS) guidelines are still not based on the best available evidence ...
Birgit Teufer, Irma Klerings, Lisa Affengruber, Agnes Ebenberger, Christina Kien, Monika Szelag, Ludwig Grillich, Ursula Griebler   +7 more
doaj   +1 more source

Global, regional, and national trends of syphilis from 1990 to 2019: the 2019 global burden of disease study

BMC Public Health, 2023
Background Syphilis is a sexually transmitted disease caused by Treponema pallidum, and the infection source is syphilis patients. This study aimed to estimate the incidence, mortality rate, and disability-adjusted life years (DALYs) of syphilis to ...
Yu-Ting Tao, Teng-Yu Gao, Hao-Yang Li, Yu-Tong Ma, Hui-Jun Li, Chen-Yang Xian-Yu, Nian-Jia Deng, Chao Zhang   +7 more
doaj   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source