HSP70 governs permeability and mechanotransduction in primary human endothelial cells
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
Efficacy of Problem Based Learning approach for teaching Evidence Based Practice in midwifery and nursing education: a systematic review. [PDF]
Komuhangi G +5 more
europepmc +1 more source
Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source
STate Activation and Response (STAR): An Evidence-Based, Practice-Informed Approach to Public Health System Improvement. [PDF]
Alongi J, Dudley J, Macchi M.
europepmc +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
The effect of implementation leadership training for nursing informal leaders in the evidence-based practice. [PDF]
Huang X +7 more
europepmc +1 more source
On Becoming a Better Therapist: Evidence-Based Practice One Client at a Time
Barry L. Duncan
openalex +1 more source
Role of systematic reviews and meta-analysis in evidence-based clinical practice
Charles D. Scales, E. McNamara
openalex +1 more source

