Results 1 to 10 of about 3,583,013 (282)

Ivacaftor for the treatment of patients with cystic fibrosis and the G551D mutation: a systematic review and cost-effectiveness analysis

Health Technology Assessment, 2014
Background: Ivacaftor (Kalydeco®, Vertex Pharmaceuticals) is the first of a new class of drugs that target the underlying protein defect in cystic fibrosis (CF).
Penny Whiting, Maiwenn Al, Laura Burgers, Marie Westwood, Steve Ryder, Martine Hoogendoorn, Nigel Armstrong, Alex Allen, Hans Severens, Jos Kleijnen   +9 more
doaj   +1 more source

Response to “Phrase truncation in PubMed searches”

Journal of the Medical Library Association, 2017
Response to Shanman R. Phrase truncation in PubMed searches [letter to the editor]. J Med Libr Assoc. 2017 Oct;105(4). DOI: http://dx.doi.org/10.5195/jmla.2017.252. Comment on Duffy S, de Kock S, Misso K, Noake C, Ross J, Stirk L. Supplementary searches
Steven Duffy, Shelley de Kock, Kate Misso, Caro Noake, Janine Ross, Lisa Stirk   +5 more
doaj   +1 more source

Overview of Differences and Similarities of Published Mixed Treatment Comparisons on Pharmaceutical Interventions for Multiple Sclerosis

Neurology and Therapy, 2020
Introduction Mixed treatment comparisons (MTCs) are increasingly important in the assessment of the benefit–risk profile of pharmaceutical treatments for relapsing–remitting multiple sclerosis (RRMS). Interpretation of MTCs requires a clear understanding
Maria Pia Sormani, Robert Wolff, Shona Lang, Steven Duffy, Robert Hyde, Elizabeth Kinter, Craig Wakeford, Gavin Giovannoni, Jos Kleijnen   +8 more
doaj   +1 more source

Procalcitonin testing to guide antibiotic therapy for the treatment of sepsis in intensive care settings and for suspected bacterial infection in emergency department settings: a systematic review and cost-effectiveness analysis

Health Technology Assessment, 2015
Background: Determination of the presence or absence of bacterial infection is important to guide appropriate therapy and reduce antibiotic exposure.
Marie Westwood, Bram Ramaekers, Penny Whiting, Florian Tomini, Manuela Joore, Nigel Armstrong, Steve Ryder, Lisa Stirk, Johan Severens, Jos Kleijnen   +9 more
doaj   +1 more source

A Systematic Review and Mixed Treatment Comparison of Pharmaceutical Interventions for Multiple Sclerosis

Neurology and Therapy, 2020
Background Since 2010, 27 mixed-treatment comparisons (MTCs) of disease-modifying therapies (DMTs) for multiple sclerosis have been published. However, there has been continued evolution in the field of MTCs.
Gavin Giovannoni, Shona Lang, Robert Wolff, Steven Duffy, Robert Hyde, Elizabeth Kinter, Craig Wakeford, Maria Pia Sormani, Jos Kleijnen   +8 more
doaj   +1 more source

Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis: a systematic review and cost-effectiveness analysis

Health Technology Assessment, 2015
Background: Patients with substantive bleeding usually require transfusion and/or (re-)operation. Red blood cell (RBC) transfusion is independently associated with a greater risk of infection, morbidity, increased hospital stay and mortality.
Penny Whiting, Maiwenn Al, Marie Westwood, Isaac Corro Ramos, Steve Ryder, Nigel Armstrong, Kate Misso, Janine Ross, Johan Severens, Jos Kleijnen   +9 more
doaj   +1 more source

Mpox surveillance in endemic regions: a scoping review of trends, challenges, and recommendations

BMC Infectious Diseases
Background Mpox continues to pose a significant public health threat in endemic regions of Africa, particularly with the emergence of new viral clades and continuous human-to-human transmission.
Fortune Benjamin Effiong, Emmanuel Ebuka Elebesunu, Tolulope Joseph Ogunniyi, Dimeji Abdulsobur Olawuyi, Emmanuel Ekpor, Monica Ahiadorme, Archibong Edem Bassey, Ibrahim Adebayo Hassan, Emmanuella Benjamin Effiong, Oluwaseun Adeolu Ogundijo, Ayomide Timilehin Kayode, Leonard Ighodalo Uzairue   +11 more
doaj   +1 more source

Rapid fetal fibronectin testing to predict preterm birth in women with symptoms of premature labour: a systematic review and cost analysis

Health Technology Assessment, 2013
Background: Premature birth is defined as birth of before 37 completed weeks' gestation. Not all pregnant women showing symptoms of preterm labour will go on to deliver before 37 weeks' gestation. Hence, addition of fetal fibronectin (fFN) testing to the
SN Deshpande, ADI van Asselt, F Tomini, N Armstrong, A Allen, C Noake, K Khan, JL Severens, J Kleijnen, ME Westwood   +9 more
doaj   +1 more source

The quality of COVID-19 systematic reviews during the coronavirus 2019 pandemic: an exploratory comparison

Systematic Reviews
Background The unprecedented volume and speed at which COVID-19-related systematic reviews (SRs) may have been produced has raised questions regarding the quality of this evidence.
Kevin T. McDermott, Mark Perry, Willemijn Linden, Rachel Croft, Robert Wolff, Jos Kleijnen   +5 more
doaj   +1 more source

Systematic Review and Network Meta‐Analysis on the Efficacy of Evolocumab and Other Therapies for the Management of Lipid Levels in Hyperlipidemia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThe proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors evolocumab and alirocumab substantially reduce low‐density lipoprotein cholesterol (LDL‐C) when added to statin therapy in patients who need additional LDL‐C reduction ...
Peter P. Toth, Gillian Worthy, Shravanthi R. Gandra, Naveed Sattar, Sarah Bray, Lung‐I. Cheng, Ian Bridges, Gavin M. Worth, Ricardo Dent, Carol A. Forbes, Sohan Deshpande, Janine Ross, Jos Kleijnen, Erik S. G. Stroes   +13 more
doaj   +1 more source