Results 121 to 130 of about 1,401,784 (268)

SAMI Matters (Spring 2003)

, 2003
A newsletter of the Ohio Substance Abuse and Mental Illness Coordinating Center of Excellence (SAMI CCOE). The SAMI CCOE is a partnership between the Cuyahoga County Community Mental Health Research Institute at the Mandel School of Applied Social ...
Center for Evidence Based Practices
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CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

SAMI Matters (Winter 2002)

, 2002
A newsletter of the Ohio Substance Abuse and Mental Illness Coordinating Center of Excellence (SAMI CCOE). The SAMI CCOE is a partnership between the Cuyahoga County Community Mental Health Research Institute at the Mandel School of Applied Social ...
Center for Evidence Based Practices
core  

Actualization of evidence-based nursing in primary, specialized, and social care settings—A cross-sectional survey [PDF]

Background: Basing practice on evidence is a widely acknowledged requirement for nursing, but shortcomings still exist. An increased understanding of the actualization of evidence-based nursing (EBN) across different nursing contexts is needed to develop
Holopainen Arja, Nyman Johanna, Pukkila Heidi, Siltanen Hannele, Hamari Lotta, Parisod Heidi   +5 more
core   +1 more source

Open fractures: evidence-based best practices

OTA International
. Open fracture management is a common challenge to orthopaedic trauma surgeons and a burdensome condition to the patient, health care, and entire society.
Paul S. Whiting, MD, FIOTA, William Obremskey, MD, MPH, MMHC, FIOTA, Herman Johal, MD, PhD, David Shearer, MD, MPH, David Volgas, MD, Zsolt J. Balogh, MD, PhD, FRACS(ortho), FACS, FIOTA   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Significance of Leaders for Sustained Use of Evidence-Based Practices: A Qualitative Focus-Group Study with Mental Health Practitioners

, 2019
Evidence-based practices that are implemented in mental health services are often challenging to sustain. In this focus-group study, 26 mental health practitioners with high fidelity scores were interviewed regarding their experiences with implementing ...
Ogden, Terje, Ruud, Torleif, Egeland, Karina M., Hauge, Mona-Iren, Heiervang, Kristin Sverdvik   +4 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Evidence-based care for nipple problems while breastfeeding

Breast milk is the most suitable and nutritious food for babies and contains all the nutrients needed for healthy growth and development. It is recommended that breast milk is given within the first hour after birth and that exclusive breastfeeding is ...
Balci, Serap, Balkan, Zeynem Yildirim
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