Results 131 to 140 of about 6,984,241 (359)

Guide to Transitional Jobs Program Design [PDF]

, 2010
This Guide to Transitional Jobs Program Design is an introduction to the essential components of the Transitional Jobs strategy. It includes an overview of the target populations for and goals of the strategy, descriptions of each program element, and ...

core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Psychological practices based on evidence and health

Interacciones
Editorial.
Diego Torres-Marruffo, Darwin Gutierrez-Guevara, Giuliana Salazar-Álvarez   +2 more
doaj   +1 more source

Innovation from user experience in Living Labs: revisiting the ‘innovation factory’-concept with a panel-based and user-centered approach [PDF]

, 2012
This paper focuses on the problem of facilitating sustainable innovation practices with a user-centered approach. We do so by revisiting the knowledge-brokering cycle and Hargadon and Sutton’s ideas on building an ‘innovation factory’ within the light of
Ballon, Pieter, De Marez, Lieven, Lievens, Bram, Schuurman, Dimitri   +3 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Open fractures: evidence-based best practices

OTA International
. Open fracture management is a common challenge to orthopaedic trauma surgeons and a burdensome condition to the patient, health care, and entire society.
Paul S. Whiting, MD, FIOTA, William Obremskey, MD, MPH, MMHC, FIOTA, Herman Johal, MD, PhD, David Shearer, MD, MPH, David Volgas, MD, Zsolt J. Balogh, MD, PhD, FRACS(ortho), FACS, FIOTA   +5 more
doaj   +1 more source

What works best: evidence based practices to help improve NSW student performance [PDF]

\u27What works best\u27 brings together seven themes from the growing bank of evidence we have for what works to improve student educational outcomes. The seven themes addressed here are:  1. High expectations 2.

core  

What You Need to Know about Bar-Code Medication Administration [PDF]

, 2019
Medication errors are the most common type of preventable error. Bar-code medication administration (BCMA) technology was designed to reduce medication administration errors.
Kuhlmann, Martha, DNP, MSN, RN, FNP, PMHCNS-BC, APRN, McBee, Marie E, DNP, MSN, Patterson, Pam, DNP, MSN, NE-BC   +2 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source