Results 171 to 180 of about 738,477 (263)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Local level of social inequity moderates implementation of evidence-based practices tailored to minoritized populations to reduce opioid overdose deaths. [PDF]

J Subst Use Addict Treat
Chatterjee A, Chase RP, Chahine RA, Davis J, Dsouza N, Ellison S, Bagley SM, Fisher T, Glasgow L, Harris MTH, Huang TT, Holloway J, Lounsbury DW, Oga E, Asman K, Roberts SM, Sabounchi N, Surratt HL, Lines LM, Stadler HW, Taylor JL, Davis A.   +21 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Assessing a behavioral nudge on healthcare leaders' intentions to implement evidence-based practices. [PDF]

PLoS One
Crawford M, O'Malley AJ, Meara E, Fraze TK, Barnato AE.   +4 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

The Place of Evidence-Based Practices in Theoretical and Clinical Practice From the Perspective of Midwifery Students: A Qualitative Study. [PDF]

J Eval Clin Pract
Aktaş Reyhan F, Dağlı E, Yeşildere Sağlam H.   +2 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Perceptions of Child-Adult Relationship Enhancement (CARE) Training Usefulness for Educational, Behavioral, and Allied Health Professionals: Attitudes Toward Evidence-Based Practices. [PDF]

J Clin Psychol Med Settings
Kiefer JL, Perry KJ, Sarver DE, Del Rosario ES, Quetsch LB.   +4 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Implementation of oral health evidence-based practices in early care education settings across the U.S. during different COVID-19 periods. [PDF]

PLoS One
Tchoua PP, Patel S, Starr AS, Rairigh R, Smith F, Willis EA.   +5 more
europepmc   +1 more source