Results 181 to 190 of about 961,861 (304)
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Business process improvement methodologies: common factors and their respective efficacies
Business process improvement (BPI) methodologies play an important role in increasing a business’s performance and its competitiveness. Since World War II, a number of these methodologies have been developed.
Nickerson, Winston
core
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Quality Improvement Intervention to Increase the Percentage of Diabetic Patients with A1c < 9.0
, 2017 Type 2 Diabetes (DM) is a leading cause of morbidity and mortality. Control of DM as measured by Hemoglobin A1c can reduce complications of the disease.
Karl Chen; Amy Locke; Susan Pohl; Katie Traylor; Michael Magill
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Oral diseases and NCDs in the Western Pacific Region need to be prioritised
The Lancet Regional Health. Western PacificLeenu Maimanuku +4 more
doaj +1 more source
Cluster randomized trial of a multilevel evidence-based quality improvement approach to tailoring VA Patient Aligned Care Teams to the needs of women Veterans. [PDF]
Implement Sci, 2016 Yano EM +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Developing a business improvement strategy based on the EFQM model
The use of the EFQM model and other business excellence models (BEM’s) has been recognised as a way of improving business processes among organisations.
Peacock, Tim +4 more
core