Results 71 to 80 of about 763,555 (302)

Editorial: Innovating and expanding universal access to oral healthcare

Frontiers in Oral Health, 2022
Bathsheba Turton, Bathsheba Turton, Callum Durward, Habib Benzian   +3 more
doaj   +1 more source

Mobilizing strategic inflection points for sustainment of an effective intervention in an integrated learning health system: an interpretive description

Implementation Science Communications
Background Innovative models of care have the potential to improve the sustainability of health systems by improving patient and provider experiences and population outcomes while simultaneously reducing costs.
Karen M. Benzies, Pilar Zanoni, Deborah A. McNeil   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Rationalising blood tests in a resource-limited emergency unit: A quality improvement project

South African Family Practice
Background: In resource-limited emergency settings, blood testing is crucial for diagnostics but can lead to financial strain and diagnostic challenges if used indiscriminately.
Renette Esterhuizen, Lilani I. Tribelhorn, Danielle M.J. Thomas, Eugenne Elliott, Talat Habib, Arun Nair   +5 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Integrating quality improvement, evidence-based practice, and knowledge translation into a health Sciences masters’ programme: a mixed methods study

BMC Medical Education
Background In recent years, the emphasis on quality improvement (QI), evidence-based practice (EBP), and knowledge translation (KT) in the education of health professionals has increased.
Per Koren Solvang, Jan Egil Nordvik, Anders Vege, Hilde Tinderholt Myrhaug   +3 more
doaj   +1 more source

Clinical Audits in Medical Education: Insights from a Cross-Sectional Study of Medical Students

International Journal of Medical Students
Background: Clinical audits are crucial for enhancing healthcare quality, but various obstacles can restrict their implementation. This study aims to examine barriers to the implementation of clinical audits among medical students and interns. Methods:
Mohammad Ghassab Deameh, Omar S Mansour, Hammam Abu Rahmeh, Baha’ Aldeen Bani Irshid, Mohammad Walid Da'meh, Enas A. Amaireh, Yazeed Badran, Jebreen A. Elaydi, Hasan M. Abu Obaideh, Suhaib Feras Fawarseh, Khaled Funjan   +10 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source