Results 141 to 150 of about 10,098,806 (296)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Living evidence profile 6.12: Best-available evidence related to the mpox outbreak

An overview of the best available research evidence from around the world (i.e., evidence syntheses) and local research evidence (i.e., single studies) and, if applicable, a scan of experiences from other countries and from Canadian provinces and ...
Alam, S, Ali, A, Wu, N, DeMaio, P, Grewal, E, Loeb, M, Bain, T, Waddell, K, Wilson, MG, Bhuiya, AR   +9 more
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Living evidence profile #6.13b: Best-available evidence related to the mpox outbreak

An overview of the best available research evidence from around the world (i.e., evidence syntheses) and local research evidence (i.e., single studies) and, if applicable, a scan of experiences from other countries and from Canadian provinces and ...
Ali, A, Sivanesanathan, T, DeMaio, P, Grewal, E, Loeb, M, Wilson, MG, Mansilla, C, Wang, Q, Whitelaw, H, Bhuiya, AR   +9 more
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Living evidence profile #6.14: Best-available evidence related to the mpox outbreak

An overview of the best available research evidence from around the world (i.e., evidence syntheses) and local research evidence (i.e., single studies) and, if applicable, a scan of experiences from other countries and from Canadian provinces and ...
Sivanesanathan, T, Ali, A, Dass, R, Grewal, E, Loeb, M, Wilson, MG, Bhuiya, AR, Cura, J   +7 more
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Unification of Digital Evidence from Disparate Sources

, 2005
This paper outlines a new approach to the acquisition and processing of digital evidence obtained from disparate digital devices and sources. To date the capture of digital based evidence has always been in its entirety from the source device and ...
Philip Turner, Digital Evidence Bags
core