Results 141 to 150 of about 25,264,236 (332)

Risk factors for postpartum depression: an umbrella review

open access: yesFrontiers in Public Health
ObjectiveThis umbrella review aimed to systematically evaluate and synthesize the evidence on risk factors associated with postpartum depression (PPD), assess the methodological quality and credibility of the existing meta-analyses, and identify high ...
Min Xu   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

On nonspecific evidence

open access: yesInternational Journal of Intelligent Systems, 1993
When simultaneously reasoning with evidences about several different events it is necessary to separate the evidence according to event. These events should then be handled independently. However, when propositions of evidences are weakly specified in the sense that it may not be certain to which event they are referring, this may not be directly ...
openaire   +2 more sources

GRADE: an emerging consensus on rating quality of evidence and strength of recommendations

open access: yesBritish medical journal, 2008
G. Guyatt   +6 more
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

“POST-INVESTIGATIVE” FAMILIARISATION WITH CRIMINAL CASE MATERIALS IN THE CONTEXT OF BALANCING PUBLIC AND PRIVATE INTERESTS

open access: yesПравовое государство: теория и практика
The article, devoted in general to evidence in criminal proceedings, focuses on the problem of standards of proof and their role in ensuring the fairness of court decisions.
ROSSINSKY Sergey Borisovich
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

LA SENTENCIA JUDICIAL COMO MEDIO DE PRUEBA THE VEREDICT AS EVIDENCE

open access: yesRevista Chilena de Derecho, 2012
Este trabajo explica la proyección probatoria que tiene una sentencia firme y ejecutoriada en el proceso civil chileno. Como acto procesal, la decisión judicial conforma una realidad jurídica y material que puede servir para acreditar un hecho en un ...
Alejandro Romero Seguel
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

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