Results 131 to 140 of about 4,985,439 (310)

Strengthening Evidence-based Family Medicine in Hong Kong [PDF]

, 2012
published_or_final_versio
Chen, JY, Chiu, BCF, Wong, WCW
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Knowledge, Attitude and Practice of Resident Physicians towards Evidence Based Medicine in Mansoura, Egypt [PDF]

, 2020
Noha Eladawi, Doaa Abdel-Hady, M Ghojazadeh, S Hajebrahimi, S Azami-Aghdash, Pournaghi Azar, F Keshavarz, M Naghavi-Behzad, M, G Guyatt, J Cairns, D Churchil, D Cook, B Haynes, J Hirsh, J Irvine, D Sackett, Wmc Rosenberg, Gam Gray, R Haynes, W Richardson, M Sadeghi, N Khanjani, F Motamedi, M Saber, G Rad, Al Omari, M Khader, Y Jadallah, K Dauod, A Al-Shdifat, A Khasawneh, N, Al-Kubaisi Nj, Al Dahnaim, L Salama, R, M Ghojazadeh, S Azami-Aghdash, Pournaghi Azar, F Fardid, M Mohseni, M Tahamtani, T, M Cranney, E Warren, S Barton, T Gardner, A Dans, L Dans, K Mathieson, E Peacock, W Chin, A Mccoll, H Smith, P White, J Field, F Barghouti, L Halaseh, T Said, A Mousa, L Al-Ansary, T Khoja, C Silagy, P Garner, M Meremikwu, J Volmink, Q Xu, H Smith, R Oliveri, C Gluud, P Wille-Jrgensen, S Ahmadi-Abhari, A Soltani, F Hosseinpanah, M Baig, Z Zaid, O Almouteri, M Algarni, H Allam, C Abeysena, P Jayawardana, R Wickremasinghe, U Wickramasinghe, R Risahmawati, S Emura, T Nishi, S Koizumi, P Hachesu, V Gavgani, Z Salahzadeh, A Ehteshami, Z Piri, M Kasaei, E Rezazadeh, M Rashidbeygi, K Sayehmiri, L Al-Ansary, T Khoja, Abdel-Kareem A; Kabbash   +99 more
openalex   +1 more source

Reply to “Ten Simple Rules for Getting Published” [PDF]

, 2007
Anon, Eric Grosch, Evidence-Based Medicine Working Group   +2 more
core   +3 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Treatment of Patients with COVID-19 and Concomitant Cardiovascular Diseases: Do not Forget About the Principles of Evidence-based Medicine

, 2020
S. Yu. Martsevich
openalex   +2 more sources

Student and educator perceptions of an evidence-based medicine research curriculum: recommendations for research curriculum development

, 2023
Dario Ferri, Clara Moore, Kyung Joon Mun, Anna Chen, Debra K. Katzman, Joyce Nyhof‐Young   +5 more
openalex   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Effectiveness of simulation-based clinical research curriculum for undergraduate medical students - a pre-post intervention study with external control

BMC Medical Education
Background Simulation is widely utilized in medical education. Exploring the effectiveness of high-fidelity simulation of clinical research within medical education may inform its integration into clinical research training curricula, finally cultivating
Qiao Huang, Si-Yu Yan, Jiao Huang, Yi Guo, Xian-Tao Zeng, Ying-Hui Jin   +5 more
doaj   +1 more source