Results 131 to 140 of about 30,821,562 (293)

Flipped classroom model for learning evidence-based medicine

, 2017
Sydney Y Rucker,1 Zulfukar Ozdogan,1 Morhaf Al Achkar2 1School of Education, Indiana University, Bloomington, IN, 2Department of Family Medicine, School of Medicine, University of Washington, Seattle, WA, USA Abstract: Journal club (JC), as a pedagogical
Al Achkar M, Rucker SY, Ozdogan Z
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Salmonella enterica mediated epigenetic promotion of fibrosis is a novel factor in benign prostatic hyperplasia

Military Medical Research
Background Fibrosis constitutes a significant pathophysiological mechanism in the clinical progression of benign prostatic hyperplasia (BPH) and represents a contributing factor to the ineffectiveness of prevailing pharmacological treatments.
Cong Zhu, Lu-Yao Li, Ming-Hui Shi, Cheng Fang, Lu Yang, Ting Li, Fei Li, Shi-Song Yang, Tian-Kun Wang, Dao-Jing Ming, Tong Deng, Hao-Yue Sun, Wen-Ting Li, Jia Zhang, Yu-Sen Zhang, Zhi-Yuan Jian, Chang-Jiang Qin, Shuang-Ying Wang, Xian-Tao Zeng   +18 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Commissioner Biographies

, 2016
List of committee members involved in the U.S.
United States. Commission on Evidence-Based Policymaking.
core  

Evidence-Based Medicine Tutorial

The Evidence-Based Medicine tutorial was one of the Evidence-Based Practice in the Health Sciences tutorials developed by UIC Library of the Health Sciences Chicago library faculty. They were originally developed with Drupal, MySQL, and PHP in 2006-2007.
Jamie Dwyer (12937449), Thomas Mantzakides (12937271), Cleo Pappas (7945256), Kristina Appelt (24567541), Estelle Hu (8003603), Lisa Wallis (5081888), Maureen Clark (20170011), Shriram Iyer (24567548), Kimberly Pendell (8003702)   +8 more
core   +1 more source

Epistemic Causality and Evidence-Based Medicine [PDF]

, 2010
Causal claims in biomedical contexts are ubiquitous albeit they are not always made explicit. This paper addresses the question of what causal claims mean in the context of disease.
Russo, Federica, Federica Russo, Jon Williamson, Williamson J., Williamson, Jon   +4 more
core  

The Philosophy of Evidence-Based Medicine

, 2011
Evidence-based medicine (EBM) has become a required element of clinical practice, but it is critical for the healthcare community to understand the ongoing controversy surrounding EBM.
Howick, Jeremy, Jeremy Howick, howick,jeremy, Howick, J   +3 more
core   +1 more source

Association Between Heart Rate at Diagnosis and Long-Term Recurrence Risk of Pulmonary Embolism in a Historical Cohort Study of Elder Women

Clinical and Applied Thrombosis/Hemostasis
To investigate the association between heart rate (HR) at diagnosis and long-term pulmonary embolism (PE) recurrence among elderly (≥ 50 year-old) female patients after acute PE (APE).
Yuan Li MD, PhD, Fang Li PhD, Meizhi Li MS, Qiong Yi MS, Shangjie Wu MD   +4 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source