ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Evidence-Based Medicine and Good Clinical Practice in Research in Pediatric and Adolescent Medicine. [PDF]
Children (Basel)Karatza AA +7 more
europepmc +1 more source
Awareness of Evidence-Based Medicine among Interns of Mashhad University of Medical Sciences, Iran [PDF]
, 2014 Hossein Ebrahimipour +6 more
openalex
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Evaluating search quality and article choice in evidence-based medicine assignments of preclinical students. [PDF]
J Med Libr AssocMagro J, Plovnick C, Nicholson J.
europepmc +1 more source
Part 2: A reader responds to "Ethics and evidence-based medicine: is there a conflict?".
, 2007 Michael A. Rie
openalex +1 more source
The Impact of Evidence-Based Medicine on Qualitative Metasynthesis: Benefits to be Harvested and Warnings to be Given [PDF]
, 2018 Kirsti Malterud
openalex +1 more source
Key role for inhibins in effective T cell activation, migration and Th17 differentiation
FEBS Open Bio, EarlyView.Activins/inhibins modulate immune responses. Here, we show that inhibins can be produced very early after T cell activation and can act in an autocrine way, favoring Th1 versus Th17 differentiation and CCL19/CCL21 mediated migration. Recombinant inhibin A can restore the Th1/Th17 balance, highlighting the role of inhibins as key regulators of T cell ...
Sandra Ortega‐Francisco +5 more
wiley +1 more source
Crosstalk in Multidisciplinary Approaches for Evidence-Based Medicine. [PDF]
J Multidiscip HealthcWang YC, Kumar S, Kung WM.
europepmc +1 more source