Results 241 to 250 of about 5,008,997 (292)

"I still have not mastered that skill!" Medical student perspectives on a simulation-based evidence-based medicine competency assessment. [PDF]

J Med Libr Assoc
Nicholson J, Plovnick C, Magro J, van der Vleuten C, de Bruin A, Kalet A.   +5 more
europepmc   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Reevaluating Mask Effectiveness: Insights From Evidence-Based Medicine and Clinical Trials. [PDF]

Cureus
Spira B.
europepmc   +1 more source

Fluoxetine: a review on evidence based medicine [PDF]

core   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Diagnostic and therapeutic management of severe acute pancreatitis. Evidence based medicine (EBM) clinical practice guidelines. [PDF]

Wideochir Inne Tech Maloinwazyjne
Szeliga J, Jagielski M, Sobocki J, Borys M, Czuczwar M, Durczyński A, Gach T, Hogendorf P, Kawiński A, Kuśnierz K, Major P, Mik M, Pędziwiatr M, Piwowarczyk P, Sierżęga M, Spychalski M, Szczeklik W, Szura M, Wierdak M, Zgodziński W, Budzyński A, Hać S, Jackowski M, Kielan W, Kukla M, Mrowiec S, Myśliwiec P, Sieńko J, Słodkowski M, Tarnowski W, Wallner G, Zawadzki M, Zieniewicz K.   +32 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Development of a Japanese version of the Fresno test for family physicians to measure evidence-based medicine competence. [PDF]

J Gen Fam Med
Kataoka Y, Maeno T, Kimura N, Ono Y, Suzuki M, Maeno T.   +5 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Update on Treatments for Parkinson's Disease Motor Fluctuations - An International Parkinson and Movement Disorder Society Evidence-Based Medicine Review. [PDF]

Mov Disord
de Bie RMA, Katzenschlager R, Swinnen BEKS, Peball M, Lim SY, Mestre TA, Perez Lloret S, Coelho M, Aquino C, Tan AH, Bruno V, Dijk JM, Heim B, Lin CH, Kauppila LA, Litvan I, Spijker R, Seppi K, Costa J, Sampaio C, Fox SH, Silverdale MA.   +21 more
europepmc   +1 more source