Results 121 to 130 of about 9,419,823 (304)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Contextual factors related to vector-control interventions for malaria: a scoping review and evidence and gap map protocol [version 1; peer review: 2 approved]

F1000Research
Objective This scoping review will identify existing literature regarding contextual factors relevant to vector-control interventions to prevent malaria. We will use the findings of the scoping review to produce an interactive evidence and gap map.
Ellie A. Akl, Carrie Price, Jan Kolaczinki, Danielle Pollock, Sabira Hasanoff, Alinune Nathanael Kabaghe, Mafalda Dias, Raju Kanukula, Timothy Hugh Barker, Grace McKenzie McBride, Zachary Munn   +10 more
doaj   +1 more source

Cochrane India and Evidence Synthesis

Journal of Medical Evidence, 2023
Meenu Singh, Anju Pradhan
openaire   +2 more sources

Synthesizing public health preparedness mechanisms for high-impact infectious disease threats: A jurisdictional scan

Aim High-impact infectious diseases pose major global health challenges, underscoring the urgent need for robust public health preparedness. Despite efforts to improve global health security, recent pandemics have revealed significant weaknesses in ...
Lavis, John N., Saif-Ur-Rahman, KM, Taneri, Petek Eylul, Horgan, Mary, Burke, Nikita, Murphy, Lena, Devane, Declan, Reynolds, Bearach, Parlour, Randal, Boland, Máirín   +9 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Comparative effectiveness of Omicron XBB 1.5-adapted COVID-19 vaccines: a systematic literature review and network meta-analysis

Expert Review of Vaccines
Introduction Comparative effectiveness data of COVID-19 vaccines remain limited. We conducted a systematic review and network meta-analysis (NMA) feasibility assessment of effectiveness studies of Omicron-adapted COVID-19 vaccines.Research design and ...
Kyle Fahrbach, Allie Cichewicz, Haitao Chu, Manuela Di Fusco, Heather Burnett, Hannah R. Volkman, Morodoluwa Akin-Fajiye, Carlos Fernando Mendoza, Joseph C. Cappelleri   +8 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Diagnostic test accuracy of simplified algorithms for diagnosing acute rheumatic fever: a systematic review

Communications Medicine
Background Rheumatic heart disease, the long-term sequel to acute rheumatic fever, remains a prevalent public health problem in Africa and other low to middle-income regions of the world.
Rui Providencia, Ghazaleh Aali, Fang Zhu, Thomas Katairo, Mahmood Ahmad, Jonathan JH Bray, Ferruccio Pelone, Eloi Marijon, Miryan Cassandra, David S. Celermajer, Farhad Shokraneh   +10 more
doaj   +1 more source

Evidence synthesis and dissemination

Canadian Urological Association Journal, 2019
Adriana, Modica, D Robert, Siemens
openaire   +3 more sources