Results 141 to 150 of about 853,340 (351)

Inhibiting cGAS‐STING to Preserve Mitochondrial–Nuclear Communication and Stemness in Young Tendon Stem Cells: A Hydrogel Strategy against Age‐Related Tendinopathy

Advanced Science, EarlyView.
A dual‐targeting strategy to rejuvenate aged tendons. A reactive oxygen species (ROS)‐responsive hydrogel co‐delivers a selenium nanozyme (scavenges ROS) and a STING inhibitor to tendon stem cells. This combined action restores mitochondria–nucleus communication, alleviates cellular senescence, and rejuvenates tendon regeneration, offering a novel ...
Zhuo Zhang, Weiyong Song, Heng Yin, Yi Wang, Yi Zou, Yuling Li, Yue Luo, Chao Xiang, Xiaoqin Liu, Yan Xiong, Yong Wang, Ke Jiang   +11 more
wiley   +1 more source

Freedom, Morality, and the Propensity to Evil [PDF]

, 2014
In Book I of the Religion within the Boundaries of Mere Reason Kant offers an explanation of freedom and moral good and evil that is different from that offered in the Groundwork for a Metaphysics of Morals.
Kahn, Samuel
core   +2 more sources

Cascade‐Responsive MXene@Cu‐MOF Heterostructure Integrates Antioxidant Activity, Infection Control, and Vascularization for Tracheal Repair

Advanced Science, EarlyView.
A cascade‐responsive MXene@Cu‐MOF/GelMA hydrogel is engineered as a “skeleton–backpack” platform for extensive tracheal repair. The MXene framework scavenges postoperative ROS and converts NIR light into mild hyperthermia, while the Cu‐MOF component provides pH/NIR‐responsive Cu2+ dosing for infection control, angiogenesis, and chondrogenesis.
Liang Guo, Yingran Shen, Jiaoyu Yi, Juanjuan Li, Ziming Wang, Erji Gao, Siqiang Zheng, Zhe‐Sheng Chen, Bo Tao   +8 more
wiley   +1 more source

Approaching Scarless Wound Healing: From Passive Anti‐Fibrotic to Proactive and Programmable Pro‐Regenerative Strategies

Advanced Science, EarlyView.
This review outlines the wound healing process and factors influencing scar formation, explores how certain animals and human fetuses achieve scarless skin or tissue regeneration, and details tissue engineering material strategies employed in scarless wound dressings.
Meimei Fu, Zhuoyi Huang, Jintao Li, Yue Li, Zhou Fang, Yiwen Jiang, Keke Wu, Jinshan Guo   +7 more
wiley   +1 more source

ORTAÇAĞ FELSEFESİNDE AHLAKİ BİR PROBLEM OLARAK "DÜNYA-ALGISI"

Felsefe Dünyası, 2010
Ortaçağ felsefesi modern dönemlerde hala tartışılmaya devam etmektedir. Rasyonalistler ortaçağları, bilim, sanat ve felsefe bakımında karanlık çağlar olarak kabul etmekte ve insanın kendisi ve dünya hakkında tasarrufta bulunma hakkının olmadığını ...
Şamil Öçal
doaj  

Neutrophil‐Mimetic Nanoscavengers Target the Inflammatory Microenvironment to Eliminate NETs/ROS and Immunomodulate cGAS‐STING Signaling in Septic AKI

Advanced Science, EarlyView.
Sepsis‐associated acute kidney injury is driven by oxidative stress, NETs overproduction, and dysregulated innate immunity. Here, we develop neutrophil‐mimetic nanoscavengers that integrate ROS‐scavenging Mn3O4 nanozymes with DNase‐1‐mediated NETs degradation to suppress cGAS‐STING signaling, reprogram macrophage polarization, and effectively alleviate
Zening Zhang, Chenxi Zhang, Ranran Luo, Qiuchi Wu, Pengchen Ren, Xinyu Liu, Yingying Luo, Zhongsheng Xu, Xiaojing He, Yun Liu   +9 more
wiley   +1 more source

METAFİZİKSEL BİR SORUN OLARAK KÖTÜLÜK

Felsefe Dünyası, 2014
Tanrı teistik dinlerde her şeyi bilen, her şeye gücü yeten ve mutlak iyiolan bir varlıktır. Yani, Tanrı mutlak ve aşkın bir zattır. Fakat ateistik yaklaşımlaragöre mutlak bilgi, güç ve iyilik gibi mükemmel niteliklerle/sıfatlarlatanımlanan bir Tanrı’nın ...
Eyüp Aktürk
doaj  

Sertoli Cell‐Derived Extracellular Vesicles Orchestrate Cadmium‐Induced Testicular Inflammation and Fibrosis

Advanced Science, EarlyView.
Environmental cadmium exposure disrupts testicular homeostasis through a novel intercellular communication axis. Stressed Sertoli cells release extracellular vesicles carrying damage‐associated molecular patterns and mitochondrial fragments, which activate macrophages via TLR4/NF‐κB signaling.
Jianfeng Ma, Mailin Gan, Shuang Liang, Siyu Chen, Ziling Hao, Yiting Yang, Jiawei Lu, Qihang Wu, Yuqian Shi, Lijun Sun, Jiaxin Li, Saihao Wang, Yan Wang, Xiaofeng Zhou, Lei Chen, Ye Zhao, Li Zhu, Linyuan Shen   +17 more
wiley   +1 more source

LAW OF “GOOD AND EVIL”, NON-LINEAR FUNCTION OF JUSTICE, POLITICAL REGIMES AND DEFORMATION OF POLITICAL SYSTEMS

Russian Journal of Economics and Law, 2015
Objective: to clarify the law of good and evil, the function (rule) of justice and to construct mathematical models of political regimes. Methods: 1) observation, analysis and synthesis; 2) deduction and induction; 3) using the laws of formal logic; 4 ...
S. G. Ol’kov
doaj  

Pain and Evil: From Local Nociception to Misery Following Social Harm

Journal of Pain Research, 2020
Mariagrazia D’Ippolito,1 Adriano Purgato,2 Maria Gabriella Buzzi1,3 1Neurorehabilitation 2, Post-Coma Unit, IRCCS Fondazione Santa Lucia, Rome 00179, Italy; 2National Health System, Azienda USL Roma 2, Rome 00157, Italy; 3Headache Centre, IRCCS ...
D'Ippolito M, Purgato A, Buzzi MG
doaj