Results 121 to 130 of about 771,683 (301)
La ética como respuesta al sufrimiento inútil en Emmanuel Levinas
Franciscanum, 2012 The aim of this article is to theme the ethic matter in Levinas’ philosophy as a reply to the senseless pain. Through the analysis of pain the author reaches the infinity of the responsibility to the Other, shown in his/her face, and consequently in God.
Analía Giménez Giubbani
doaj
Advanced Science, EarlyView.The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther +13 more
wiley +1 more source
, 2012 In contrast to traditional systems of thought which regarded evil as a supernatural force that explained human misfortune, Michel Wieviorka develops a sociological analysis of evil phenomena.
Taylor, Jo, Wieviorka, Michel
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Advanced Science, EarlyView.ABSTRACT Colorectal cancer (CRC) remains therapeutically challenging due to high metastasis, recurrence, and immunotherapy resistance driven by tumor microenvironment‐mediated immune evasion. Immunogenic cell death (ICD) offers a promising strategy to reshape the immune microenvironment, yet existing ICD inducers suffer from poor targeting efficiency ...
Yao Xiao +12 more
wiley +1 more source
Das Problem des Bösen in der Philosophie Józef Tischners [PDF]
Argument, 2011 The paper presents several understandings of evil distinguished by Józef Tischner, like the axiological evil, agathological evil and structural evil.
Tadeusz GADACZ
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Goblins, Greed, and Goodness: The Symbolic and Narrative Degradation of Goblins within The Hobbit [PDF]
, 2015 Throughout The Hobbit, J.R.R Tolkien establishes a variety of races that range on a diverse scale of good and evil. Within this spectrum, Goblins are portrayed as being the most evil in comparison to every other race on Middle Earth. Tolkien utilizes a
Stine, Katelyn
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CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction
Advanced Science, EarlyView.CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma +12 more
wiley +1 more source
The Role of Extracellular Vesicles MicroRNAs in Sarcopenia: From Aging to Multi‐Morbidity
AGING MEDICINE, EarlyView.Exosomes transporting miRNAs play a crucial bidirectional regulatory role in the process of sarcopenia, both in natural aging and under various pathological conditions. ABSTRACT Sarcopenia, defined as progressive loss of skeletal muscle mass and function, occurs during aging and has also been recognized for its detrimental effects in various disease ...
Bingyu Huang, Zhao Peng, Lin Kang
wiley +1 more source
Pursuing Pankalia: The Aesthetic Theodicy of St. Augustine [PDF]
, 2016 This chapter summarizes Augustine’s often-neglected aesthetic theodicy that balances his metaphysical definitions of evil and human agency against the ultimately beautiful story Augustine sees God, as the author of all Creation, writing. First, Augustine’
Holdier, A. G.
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Explaining the Origin of Negative Poisson's Ratio in Amorphous Networks With Machine Learning
Advanced Intelligent Discovery, EarlyView.This review summarizes how machine learning (ML) breaks the “vicious cycle” in designing auxetic amorphous networks. By transitioning from traditional “black‐box” optimization to an interpretable “AI‐Physics” closed‐loop paradigm, ML is shown to not only discover highly optimized structures—such as all‐convex polygon networks—but also unveil hidden ...
Shengyu Lu, Xiangying Shen
wiley +1 more source