Results 101 to 110 of about 771,683 (301)

Methylglyoxal Accumulation is Associated with Brain Inflammation after Myocardial Infarction with Sex and Regional Differences

open access: yesAdvanced Science, EarlyView.
This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley   +1 more source

"See no evil, hear no evil, speak no evil"

open access: yes, 2018
A PBS documentary synthetizes Donald Trump’s comments about his belief that some people are genetically superior than others. The eugenic ideal is the antithesis of the self-made man American value and is a controversial view among Deaf Americans that still remember the work of Alexander Graham Bell.
openaire   +2 more sources

Untamed God or Reckless Risk-Taker? A Reply to Hasker\u27s Natural Order Theodicy [PDF]

open access: yes, 2017
This paper argues that Molinism best rebuts the problem of natural evil when compared to the attempts of Open Theists, particularly William Hasker. The author begins by summarizing Hasker\u27s own Natural Order Theodicy, and subsequently critiques it. He
Justice, Nathan S
core   +1 more source

The Limits of Theodicy: An Eastern Orthodox Perspective on Evil and Interreligious Theology [PDF]

open access: yes, 2016
This essay is written from the vantage point of a comparative theologian who is personally steeped in the Eastern Orthodox Christian tradition and who primarily specializes in Christian-Muslim comparative theology.
Monge, Rico G.
core   +3 more sources

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

open access: yesAdvanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong   +24 more
wiley   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

open access: yesAdvanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong   +8 more
wiley   +1 more source

Evil, Freedom and Heaven [PDF]

open access: yes, 2018
By far the most respected response by theists to the problem of evil is some version of the free will defense, which rests on the twin ideas that God could not create humans with free will without them committing evil acts, and that freedom is of such ...
Cushing, Simon
core  

A Synergistic Hydrogel‐Microalgae Platform for Dual‐Targeting of Intestinal and Neuroimmune Dysfunction in Inflammatory Bowel Disease

open access: yesAdvanced Science, EarlyView.
A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu   +8 more
wiley   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

open access: yesAdvanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi   +15 more
wiley   +1 more source

Lead Us Not Into Temptation, Deliver Us From Evil (Chapter in The Lord\u27s Prayer, Smyth & Helwys Bible Commentary)

open access: yes, 2017
I recall, as a young child, having a number of superstitious assumptions. I remember being afraid of the dark, and at night, as I stood in my doorway, I believed that when I turned off the light switch I had to jump to my bed (for some reason thinking ...
Gupta, Nijay K.
core  

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