Results 31 to 40 of about 32,909 (243)

Auditory Hair Cell Mechanotransduction Channels Dynamically Shape the Mechanical Properties of Their Membrane Environment

Advanced Science, EarlyView.
This work shows, for the first time, that the stereocilia membrane in cochlear hair cells is dynamically regulated by the mechanotransduction channel to impact the membrane mechanical properties. This work provides direct evidence that the opening and closing associated with the MET channel is regulating the membrane viscosity suggesting that the MET ...
Shefin S. George, Anthony J. Ricci
wiley   +1 more source

Hydranencephaly in Neonates

Pediatrics and Neonatology, 2008
Hydranencephaly is characterized by severe dysgenesis of the cerebral hemispheres, with relative preservation of the thalamus, cerebellum and brainstem.
Jeng-Dau Tsai, Huang-Tsung Kuo, I-Ching Chou   +2 more
doaj   +1 more source

Nurr1 Orchestrates Claustrum Development and Functionality

Advanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan, Andrew G. Newman, Pauline Lange, Susanne Müller, Marco Foddis, Stefan Paul Koch, Philipp Böhm‐Sturm, Maron Mantwill, Carsten Finke, Penghui Deng, Melissa Long, Dietmar Schmitz, Victor Tarabykin   +12 more
wiley   +1 more source

Speech-Induced Suppression for Delayed Auditory Feedback in Adults Who Do and Do Not Stutter

Frontiers in Human Neuroscience, 2020
Speech-induced suppression is the normal, relative amplitude reduction of the auditory evoked potential for self-, compared to externally-generated, auditory stimulation. It remains controversial as to whether adults who stutter exhibit expected auditory
Akira Toyomura, Daiki Miyashiro, Daiki Miyashiro, Shinya Kuriki, Paul F. Sowman, Paul F. Sowman   +5 more
doaj   +1 more source

Brainstem auditory evoked potentials in Parkinson's disease [PDF]

Romanian Journal of Neurology, 2013
Background. Parkinson’s disease is a neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra, but also in other dopaminergic and nondopaminergic areas of the brain and mainly in the brainstem.
Daniel Alexa, Laura Alexa, Livia Popa, Dan Nicolae Paduraru, Bogdan Ignat, Aurora Constantinescu, Doru Baltag, Alexandrina Rotar, Cristian Dinu Popescu   +8 more
doaj   +1 more source

Electrical Control of the Transduction Channels’ Gating Force in Mechanosensory Hair Cells

Advanced Science, EarlyView.
The inner ear's hair cells rely on mechanosensitive ion channels to convert vibrations of their hair‐bundle into electrical signals. We show that varying the electrical potential (U) across the sensory epithelium modulates a key determinant of mechanosensitivity—the gating force (FG)—by modulating the gating swing (d), ranging from the size of the ...
Achille Joliot, Laure Stickel, Pascal Martin   +2 more
wiley   +1 more source

Initial absence of N20 waveforms from median nerve somatosensory evoked potentials in a patient with cardiac arrest and good outcomes [PDF]

Clinical and Experimental Emergency Medicine, 2019
A 34-year-old male was brought to the hospital with a chest gunshot wound. Pulseless upon arrival, blood pressure was absent for 10 minutes. A thoracotomy resulted in return of spontaneous circulation.
Miguel E. Habeych, Pouria Moshayedi, Jon C. Rittenberger, Scott R. Gunn   +3 more
doaj   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Changes in Auditory Evoked Potentials Increase the Chances of Adults Having Central Auditory Processing Disorder

International Archives of Otorhinolaryngology
Introduction Auditory evoked potentials are widely used in clinical practice to complement the assessment of central auditory processing.
Andressa Pelaquim, Milaine Dominici Sanfins, Marco Aurélio Fornazieri   +2 more
doaj   +1 more source

The Geometry of Layer 2/3 Cortical Sound Processing in Slow Wave Sleep

Advanced Science, EarlyView.
Sleep is associated with a sensory disconnection whose mechanisms remain elusive. Large neuronal population recordings in the auditory cortex revealed that, in NREM sleep, the neural code for sounds is highly similar to wakefulness, but coordinated modulations of neuron responsiveness intermittently disconnect the local cortical networks from sensory ...
Allan Muller, Anton Filipchuk, Sophie Bagur, Brice Bathellier   +3 more
wiley   +1 more source