Results 51 to 60 of about 78,465 (231)

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

Cortical Auditory Evoked Potentials in 2-Year-Old Subjects

International Archives of Otorhinolaryngology, 2020
Introduction Cortical auditory evoked potentials (CAEPs) can be used to evaluate both peripheral and cortical components of auditory function, and contribute to the assessment of functional sensitivity and auditory thresholds, especially in neonates and ...
Inaê Costa, Ayra Renata D'Agostini, Jennifer Alves Sousa, Ana Paula Ramos de Souza, Eliara Pinto Vieira Biaggio   +4 more
doaj   +1 more source

Neurochemical substrates and neuroanatomical generators of the event-related P300 [PDF]

, 1999
The present review focuses on the current knowledge of the neurochemical processes and neuronal structures involved in the generation of P300. The increasing knowledge in this area facilitates the physiological interpretation of P300 findings as well as ...
Bottlender, Ronald, Frodl-Bauch, Thomas, Hegerl, Ulrich   +2 more
core   +1 more source

Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound

Advanced Science, EarlyView.
In this study, Qiu et al. found that low‐intensity ultrasound can directly activate sparse ultrasound‐sensitive neurons (UNs) in the primary visual cortex (V1) of deafened mice. The proportion of these sparse UNs is pressure‐dependent. Furthermore, ultrasound modulates visual circuitry with distinct excitatory and inhibitory effects.
Jiaru He, Jiejun Zhu, Xinxin Wang, Zihao Chen, Jin Yang, Zhen Yuan, Hongzhi Xu, Lei Sun, Zhihai Qiu   +8 more
wiley   +1 more source

Changes in Auditory Evoked Potentials Increase the Chances of Adults Having Central Auditory Processing Disorder

International Archives of Otorhinolaryngology
Introduction Auditory evoked potentials are widely used in clinical practice to complement the assessment of central auditory processing.
Andressa Pelaquim, Milaine Dominici Sanfins, Marco Aurélio Fornazieri   +2 more
doaj   +1 more source

The Correlative Analysis of Amplitude-temporal Characteristics of Evoked Potentials of Brain Cortex in Sportsmen [PDF]

, 2017
The article considers the correlative analysis of amplitude-temporal characteristics of evoked potentials of brain cortex in sportsmen of playing kinds of sport and athletes at perception and processing of significant information “What” and “Where” in ...
Poruchynska, T. (Tеtiana), Romaniuk, A. (Alona), Shevchuk, T. (Tеtiana), Usova, O. (Oksana), Zhuravlov, O. (Oleksandr)   +4 more
core   +2 more sources

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

Monitoring the Efficacy of Auditory Training through Changes in Brainstem and Cortical Auditory Evoked Potentials: A Systematic Review

The Egyptian Journal of Otolaryngology
Introduction Auditory training (AT) exercises as the main part of auditory rehabilitation have emerged as a promising method for enhancing auditory perception and communication skills in individuals with hearing impairments or difficulties in auditory ...
Ali Hajimohammadi, Fatemeh Heidari
doaj   +1 more source

Clinical implications of intraoperative eABRs to the Evo®-CI electrode array recipients

Brazilian Journal of Otorhinolaryngology, 2022
Introduction: Electrically evoked auditory brainstem responses provide reliable clinical information to assist professionals in the auditory rehabilitation of cochlear implant users.
Fabiana Danieli, Ana Cláudia Mirândola Barbosa Reis, Eduardo Tanaka Massuda, Maria Stella Arantes do Amaral, Michel Hoen, Dan Gnansia, Miguel Ângelo Hyppolito   +6 more
doaj   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source