Results 131 to 140 of about 180,175 (329)

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

British Journal of Pharmacology, EarlyView.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert, Chantal Fitterer, Sylvain Hugel, Mila Jesic, Yannick Goumon, Virgine Andry, Severine Schneider, Francois Daubeuf, Abdelfattah Faouzi, Stephane Doridot, Susruta Majumdar, Frederic Bihel, Martine Schmitt, Dominique Massotte   +13 more
wiley   +1 more source

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann, Mariana O. Popa, Karen T. Elvers, Misa Oyama, Daniel Ulrich, Marcus Hanley, Gui Jie Feng, Thomas Hathaway, William T. Ralvenius, Thomas Grampp, Dietmar Benke, John R. Atack, Hanns Ulrich Zeilhofer   +12 more
wiley   +1 more source

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

Accuracy of heartbeat perception is reflected in the amplitude of the heartbeat-evoked brain potential. [PDF]

, 2004
Ahern, Augustine, Aziz, Aziz, Bajwa, Bechara, Bennarroch, Berthoud, Bloch-Salisbury, Cameron, Carrillo-de-la-Pena, Cass, Covington, Critchley, Damasio, Damasio, Devrim, Dirlich, Dirlich, Ehlers, Ehlers, Fallen, Ferguson, Franssen, Furlong, Gratton, Hanamori, Hari, Hashimoto, Hillyard, Hjorth, Hobson, Hobson, Hollerbach, Hollerbach, Jaening, Jaening, Jones, Jones, Katkin, Kekoni, King, Knafelc, Leopold, Montoya, Montoya, Mussgay, Nakajima, Nieuwenhuys, Oppenheimer, Picton, Riordan, Rosen, Rosen, Schandry, Schandry, Schandry, Schandry, Schnitzler, Schnitzler, Shimojo, Tougas, Trejo, Webster, Weitkunat, Weitkunat, Weitkunat, Yoon   +67 more
core   +1 more source

Simultaneous encoding of sensory features: the role of multiplexing and noise in tactile perception and neural representation

Biological Reviews, EarlyView.
ABSTRACT The nervous system's capacity to process complex stimuli has long intrigued neuroscientists, with multiplexing now recognized as a fundamental neural coding strategy. Multiplexing refers to the simultaneous encoding of multiple stimulus features via vi distinct components of neuronal responses, such as firing rates and precise temporal spike ...
Mohammad Amin Kamaleddin
wiley   +1 more source

Predictive Performance of Machine Learning with Evoked Potentials for SCI and MS Prognosis: A Meta-Analysis

Clinical and Translational Neuroscience
Evoked potentials (EPs), including somatosensory evoked potentials (SSEPs) and motor evoked potentials (MEPs), are used to assess neural conduction in spinal cord injury (SCI) and multiple sclerosis (MS), conditions marked by demyelination, inflammation,
Constantinos Koutsojannis, Dionysia Chrysanthakopoulou   +1 more
doaj   +1 more source

Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms

Cell Proliferation, EarlyView.
Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng, Zuping Wu, Mengjie Wu, Liang Xie, Qianming Chen   +4 more
wiley   +1 more source

Recommendations of the International Society of Intraoperative Neurophysiology for intraoperative somatosensory evoked potentials

Clinical Neurophysiology, 2019
D. Macdonald, Charles C Dong, R. Quatrale, F. Sala, S. Skinner, F. Soto, A. Szelényi   +6 more
semanticscholar   +1 more source

Sensory network dysregulation in type 2 diabetes: Linking olfactory, visual, and cognitive function

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims This study investigates the relationship between multisensory (visual, somatosensory, and olfactory) dysfunction and cognitive decline in Type 2 diabetes (T2D), with a particular focus on the mediating role of olfactory dysfunction. Methods We used resting‐state fMRI to assess seed‐based functional connectivity from the primary sensory ...
Qian Li, Xin Li, Yan Bi, Jiaming Lu, Yi Zhang, Min Wu, Xinyi Shen, Zhengyang Zhu, Xin Zhang, Yining Chao, Zhou Zhang, Wen Zhang, Bing Zhang   +12 more
wiley   +1 more source