Results 1 to 10 of about 356,019 (243)

Differential Oligomerization of Alpha versus Beta Amino Acids and Hydroxy Acids in Abiotic Proto-Peptide Synthesis Reactions

Life, 2022
The origin of biopolymers is a central question in origins of life research. In extant life, proteins are coded linear polymers made of a fixed set of twenty alpha-L-amino acids.
Moran Frenkel-Pinter, Kaitlin C. Jacobson, Jonathan Eskew-Martin, Jay G. Forsythe, Martha A. Grover, Loren Dean Williams, Nicholas V. Hud   +6 more
doaj   +1 more source

Feeding Our Microbiota: Stimulation of the Immune/Semiochemical System and the Potential Amelioration of Non-Communicable Diseases

Life, 2022
Non-communicable diseases are those conditions to which causative infectious agents cannot readily be assigned. It is increasingly likely that at least some of these conditions are due to the breakdown of the previously mutualistic intestinal microbiota ...
David Smith, Sohan Jheeta, Hannya V. Fuentes, Miryam Palacios-Pérez   +3 more
doaj   +1 more source

Microbiome–Gut Dissociation in the Neonate: Autism-Related Developmental Brain Disease and the Origin of the Placebo Effect

Gastrointestinal Disorders, 2022
While the importance of the intestinal microbiome has been realised for a number of years, the significance of the phrase microbiota–gut–brain axis is only just beginning to be fully appreciated.
David Smith, Sohan Jheeta, Hannya V. Fuentes, Bernadette Street, Miryam Palacios-Pérez   +4 more
doaj   +1 more source

Microbiome–Gut Dissociation in the Neonate: Obesity and Coeliac Disease as Examples of Microbiome Function Deficiency Disorder

Gastrointestinal Disorders, 2022
The purpose of this article is to provide a direction for translational research based on an analysis of the nature of complex, immune-related conditions such as obesity and coeliac disease.
David Smith, Miryam Palacios-Pérez, Sohan Jheeta   +2 more
doaj   +1 more source

Thioesters provide a plausible prebiotic path to proto-peptides

Nature Communications, 2022
One of the early processes enabling the origins of life is thought to be the condensation of building blocks into oligomers and polymers. In this article, the authors report the synthesis of thiodepsipeptides and HS-peptides under mild temperatures and ...
Moran Frenkel-Pinter, Marcos Bouza, Facundo M. Fernández, Luke J. Leman, Loren Dean Williams, Nicholas V. Hud, Aikomari Guzman-Martinez   +6 more
doaj   +1 more source

The Enclosed Intestinal Microbiome: Semiochemical Signals from the Precambrian and Their Disruption by Heavy Metal Pollution

Life, 2022
It is increasingly likely that many non-communicable diseases of humans and associated animals are due to the degradation of their intestinal microbiomes, a situation often referred to as dysbiosis.
David Smith, Miryam Palacios-Pérez, Sohan Jheeta   +2 more
doaj   +1 more source

Microbiome–Gut Dissociation: Investigating the Origins of Obesity

Gastrointestinal Disorders, 2021
The reduction of excessive weight remains a major public health challenge, with control currently limited to a calorie reduction strategy. Currently, attempts are being made at revisiting the fibre hypothesis based on the African studies of Denis Burkitt,
David Smith, Sohan Jheeta
doaj   +1 more source

Prevalent emergence of reciprocity among cross-feeding bacteria

ISME Communications, 2022
Explaining the de novo evolution of obligate cooperative cross-feeding interactions among bacteria is a fundamental problem. A critical step during this process is the emergence of reciprocity among two interaction partners, because a mutually beneficial
Samir Giri, Ghada Yousif, Shraddha Shitut, Leonardo Oña, Christian Kost   +4 more
doaj   +1 more source

Mutually stabilizing interactions between proto-peptides and RNA

Nature Communications, 2020
Cooperative relationships are widespread among different classes of biopolymers and are predicted to have existed during emergence of life. This study shows that proto-peptides engage in mutually stabilizing interactions with RNA, providing support for ...
Moran Frenkel-Pinter, Jay W. Haynes, Ahmad M. Mohyeldin, Martin C, Alyssa B. Sargon, Anton S. Petrov, Ramanarayanan Krishnamurthy, Nicholas V. Hud, Loren Dean Williams, Luke J. Leman   +9 more
doaj   +1 more source

Physiological characterization of a new thermotolerant yeast strain isolated during Brazilian ethanol production, and its application in high-temperature fermentation

Biotechnology for Biofuels, 2020
Background The use of thermotolerant yeast strains can improve the efficiency of ethanol fermentation, allowing fermentation to occur at temperatures higher than 40 °C.
Cleiton D. Prado, Gustavo P. L. Mandrujano, Jonas. P. Souza, Flávia B. Sgobbi, Hosana R. Novaes, João P. M. O. da Silva, Mateus H. R. Alves, Kevy P. Eliodório, Gabriel C. G. Cunha, Reinaldo Giudici, Diele P. Procópio, Thiago O. Basso, Iran Malavazi, Anderson F. Cunha   +13 more
doaj   +1 more source