Results 101 to 110 of about 331,108 (267)

Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases

FEBS Letters, EarlyView.
Igor Zivkovic, Morana Dulic, Ita Gruic‐Sovulj   +2 more
wiley   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

Strong He i Emission Lines in High N/O Galaxies at z ∼ 6 Identified in JWST Spectra: High He/H Abundance Ratios or High Electron Densities?

The Astrophysical Journal
We present He i /H β flux and He/H abundance ratios in three James Webb Space Telescope galaxies with significant constraints on N/O abundance ratios, GS-NDG-9422, RXCJ2248-ID, and GLASS150008 at z ∼ 6 mostly with the spectroscopic coverage from He i λ ...
Hiroto Yanagisawa, Masami Ouchi, Kuria Watanabe, Akinori Matsumoto, Kimihiko Nakajima, Hidenobu Yajima, Kentaro Nagamine, Koh Takahashi, Minami Nakane, Nozomu Tominaga, Hiroya Umeda, Hajime Fukushima, Yuichi Harikane, Yuki Isobe, Yoshiaki Ono, Yi Xu, Yechi Zhang   +16 more
doaj   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Potential-driven Metal Cycling: JADES Census of Gas-phase Metallicity for Galaxies at 1 < z < 7

The Astrophysical Journal Letters
The gravitational potential is established as a critical determinant of gas-phase metallicity (12+log(O/H)) in low-redshift galaxies, whereas its influence remains unconfirmed at high redshifts.
Cheng Jia, Enci Wang, Cheqiu Lyu, Chengyu Ma, Jie Song, Yangyao Chen, Kai Wang, Haoran Yu, Zeyu Chen, Jinyang Wang, Yifan Wang, Xu Kong   +11 more
doaj   +1 more source

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

FEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter, James Larson, Monika Tokmina‐Lukaszewska, Jin Xiong, Jared Green, Yisong Guo, William E. Broderick, Brian Bothner, Joan B. Broderick   +8 more
wiley   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Amorphous Cu-Mn hopcalite as novel Fenton-like catalyst for H2O2-activated degradation of tetracycline at circumneutral pH

Journal of Science: Advanced Materials and Devices, 2023
Cu-Mn hopcalite, as a conventional catalyst showing potential in many chemical reactions, has been rarely researched for its applications in H2O2-activated Fenton-like reactions for the decomposition of refractory pollutants.
Ying Liu, Shixian Huang, Helen J. Sun, Yao Liu, Lijiao Liang, Qingwei Nan, Tao Wang, Zhengzheng Chen, Jianting Tang, Chuanbo Hu, Joe R. Zhao   +10 more
doaj  

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source