Results 111 to 120 of about 331,108 (267)

Chemical Doppelgangers in GALAH DR3: The Distinguishing Power of Neutron-capture Elements among Milky Way Disk Stars

The Astrophysical Journal
The observed chemical diversity of Milky Way stars places important constraints on Galactic chemical evolution and the mixing processes that operate within the interstellar medium. Recent works have found that the chemical diversity of disk stars is low.
Catherine Manea, Keith Hawkins, Melissa K. Ness, Sven Buder, Sarah L. Martell, Daniel B. Zucker   +5 more
doaj   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Functional role and folding properties of the glucan‐binding domain of oral bacterial glucansucrase

FEBS Letters, EarlyView.
The role of the glucan‐binding domain in Streptococcus sobrinus glucansucrase was examined, focusing on its impact on enzymatic activity, dextran binding, and structural stability of deletion mutants and a circularly permuted protein. Our research revealed that glucosyl transfer efficiency is linked to cooperative interdomain folding.
Hideyuki Komatsu, Takayuki Sadakane, Yudai Murata, Junichi Taira, Hiroshi Sakamoto, Takao Kodama   +5 more
wiley   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

The chemical evolution of galaxies

Metals -- heavy elements synthesized during various phases of stellar evolution or during supernova explosions -- play a fundamental role in shaping galaxy evolution. In fact, their relative abundances, spatial distribution, and scaling with galactic properties reflect the constant interplay between star-formation, nucleosynthesis, and gas flows that ...
openaire   +2 more sources

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

EMPRESS. XIII. Chemical Enrichment of Young Galaxies Near and Far at z ∼ 0 and 4–10: Fe/O, Ar/O, S/O, and N/O Measurements with a Comparison of Chemical Evolution Models

The Astrophysical Journal
We present gas-phase elemental abundance ratios of thirteen local extremely metal-poor galaxies (EMPGs), including our new Keck/LRIS spectroscopy determinations together with 33 James Webb Space Telescope z ∼ 4–10 star-forming galaxies in the literature,
Kuria Watanabe, Masami Ouchi, Kimihiko Nakajima, Yuki Isobe, Nozomu Tominaga, Akihiro Suzuki, Miho N. Ishigaki, Ken’ichi Nomoto, Koh Takahashi, Yuichi Harikane, Shun Hatano, Haruka Kusakabe, Takashi J. Moriya, Moka Nishigaki, Yoshiaki Ono, Masato Onodera, Yuma Sugahara   +16 more
doaj   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

The Milky Way Radial Metallicity Gradient as an Equilibrium Phenomenon: Why Old Stars Are Metal Rich

The Astrophysical Journal
Metallicities of both gas and stars decline toward large radii in spiral galaxies, a trend known as the radial metallicity gradient. We quantify the evolution of the metallicity gradient in the Milky Way as traced by APOGEE red giants with age estimates ...
James W. Johnson, David H. Weinberg, Guillermo A. Blanc, Ana Bonaca, Gwen C. Rudie, Yuxi (Lucy) Lu, Bronwyn Reichardt Chu, Emily J. Griffith, Tawny Sit, Jennifer A. Johnson, Liam O. Dubay, Miqaela K. Weller, Daniel A. Boyea, Jonathan C. Bird   +13 more
doaj   +1 more source