Results 121 to 130 of about 7,622,829 (352)

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Neuropeptidergic Systems in Pluteus Larvae of the Sea Urchin Strongylocentrotus purpuratus: Neurochemical Complexity in a “Simple” Nervous System

Frontiers in Endocrinology, 2018
The nervous system of the free-living planktonic larvae of sea urchins is relatively “simple,” but sufficiently complex to enable sensing of the environment and control of swimming and feeding behaviors.
Natalie J. Wood, Teresa Mattiello, Teresa Mattiello, Matthew L. Rowe, Matthew L. Rowe, Lizzy Ward, Lizzy Ward, Margherita Perillo, Maria Ina Arnone, Maurice R. Elphick, Paola Oliveri   +10 more
doaj   +1 more source

The Impact of Nuclear Physics Uncertainties on Galactic Chemical Evolution Predictions [PDF]

arXiv, 2019
Modeling the evolution of the elements in the Milky Way is a multidisciplinary and challenging task. In addition to simulating the 13 billion years evolution of our Galaxy, chemical evolution simulations must keep track of the elements synthesized and ejected from every astrophysical site of interest (e.g., supernova, compact binary merger).
arxiv  

The building up of the disk galaxy M33 and the evolution of the metallicity gradient

, 2007
The evolution of radial gradients of metallicity in disk galaxies and its relation with the disk formation are not well understood. Theoretical models of galactic chemical evolution make contrasting predictions about the time evolution of metallicity ...
Aller, Arnett, Aubert, Beaulieu, Block, Block, Brooks, Bullock, Chabrier, Chang, Chiappini, Chiappini, Chiappini, Chieffi, Ciardullo, Ciardullo, Corbelli, Corbelli, Crockett, D. Galli, Davidge, de Boer, Devereux, Diaz, E. Corbelli, Elmegreen, Engargiola, Ferrini, Ferrini, Ferrini, Ferrini, Freedman, Freeman, Friel, Gallagher, Galletti, Garnett, Gavilán, Goetz, Henry, Henry, Henry, Herrero, Herwig, Heyer, Hippelein, Hirschi, Holmberg, Hoopes, Hou, Israel, Kennicutt, Kennicutt, Kennicutt, Keres, Kim, Koeppen, Kroupa, Kroupa, Kwitter, L. Magrini, Maciel, Maciel, Maciel, Maciel, Magrini, Magrini, Magrini, Marigo, McCarthy, McConnachie, Mollà, Mollà, Mollà, Monteverde, Monteverde, Naab, Newton, Portinari, Portinari, Regan, Richer, Romano, Rowe, Salpeter, Sandage, Scalo, Scalo, Smith, Stanghellini, Stephens, Talbot, Thielemann, Tiede, Tinsley, Tosi, Urbaneja, Venn, Vílchez, Wakker, Westmeier, Willner, Woosley, Wyse, Young   +104 more
core   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Domains of States of Chemical Systems: Le Chatelier Response, Structure of the Domains and Evolution [PDF]

arXiv, 2005
The paper investigates influence of the Le Chatelier response on the chemical system behavior under stress, the shape of its domains of states in terms of static and dynamic bifurcation diagrams, and the system proneness to evolution. The usage of maps in thermodynamics of chemical systems is discussed.
arxiv  

The Chemical Evolution of the Milky Way

, 1999
The field of chemical evolution modeling of the Galaxy is experiencing in the last years a phase of high activity and important achievements. There are, however, several open questions which still need to be answered. In this review I summarize what have
A Pasquali, A Renzini, AA Penzias, AI Boothroyd, B Barbuy, B Edvardsson, C Chiappini, CG Lacey, E Anders, F Matteucci, Forestini, JM Scalo, LB van den Hoek, M Tosi, M Tosi, M Tosi, M Tosi, N Prantzos, P Kroupa, PA Shaver, R Wielen, Rocha, S Boissier, S Smartt, SE Woosley, T.C. Beers, WJ Maciel, WJ Maciel   +27 more
core   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Thermodynamic evolution theorem for chemical reactions

Physical Review Research, 2020
The production, exchange, and balance of entropy characterize the thermodynamics of open nonequilibrium systems, ranging from chemical reactions, cells, ecological systems, and Earth-like planets to stars.
David Hochberg, Josep M. Ribó
doaj   +1 more source

The equilibrium theory of life evolution [PDF]

arXiv, 2005
Apparent biodiversity on earth exists only if we compare different species separated from their environments. Meanwhile coexisting species have to be identical in terms of energetic interactions. Consider the biosphere as a network of chemical reactions. This leads to the conclusion that forces which drive life evolution may be found inside the process
arxiv