Results 141 to 150 of about 6,342,096 (314)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Molecular evolution of Bowman-Birk type proteinase inhibitors in flowering plants

, 2003
The Bowman-Birk family (BBI) of proteinase inhibitors is probably the most studied family of plant inhibitors. We describe the primary structure and the gene expression profile of 14 putative BBIs from the sugarcane expressed sequence tag database and ...
Silva-Filho, M. C., Mello, M. O., Tanaka, A. S.   +2 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Selection in molecular evolution

Studies in History and Philosophy of Science
Evolution requires selection. Molecular/chemical/preDarwinian evolution is no exception. One molecule must be selected over another for molecular evolution to occur and advance. Evolution, however, has no goal. The laws of physics have no utilitarian desire, intent or proficiency.
openaire   +2 more sources

Erratum to: Positive selection neighboring functionally essential sites and disease-implicated regions of mammalian reproductive proteins

BMC Evolutionary Biology, 2017
Claire C Morgan, Noeleen B Loughran, Thomas A Walsh, Alan J Harrison, Mary J O’Connell   +4 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The Evolution of Molecular Computation [PDF]

Science, 1995
openaire   +2 more sources

Plastid phylogenomic insights into the evolution of Caryophyllales

, 2019
The Caryophyllales includes 40 families and 12,500 species, representing a large and diverse clade of angiosperms. Collectively, members of the clade grow on all continents and in all terrestrial biomes and often occupy extreme habitats (e.g., xeric ...
Yao, Gang, Li, De-Zhu, Soltis, Douglas, Moore, Michael, Brockington, Samuel, Smith, Stephen, Douglas, Norman A., Christenhusz, Maarten, Yang, Jun-Bo, Mostow, Rebecca, Christenhusz, Maarten J.M., Li, Hong-Tao, Soltis, Pamela, Mandala, Venkata, Jin, Jian-Jun, Croley, Matthew, Chase, Mark, Chase, Mark W., Yi, Ting-Shuang, Douglas, Norman   +19 more
core   +1 more source

Filtration of airborne eDNA outperforms leaf swabs for terrestrial vertebrate detection in a temperate mixed forest with longer filtration times performing the best

Methods in Ecology and Evolution
Advances in collection of environmental DNA (eDNA) through active air filtration and sampling from vegetation (leaf swabs) have demonstrated the promise of using airborne eDNA for terrestrial vertebrate surveys.
Kasun H. Bodawatta, Agnete l. M. Madsen, Christina Lynggaard, Kristine Bohmann   +3 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source