Results 121 to 130 of about 6,342,096 (314)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Adaptive Molecular Evolution in the Opsin Genes of Rapidly Speciating Cichlid Species

, 2005
Cichlid fish inhabit a diverse range of environments that vary in the spectral content of light available for vision. These differences should result in adaptive selective pressure on the genes involved in visual sensitivity, the opsin genes.
Spady, Tyrone C., Seehausen, Ole, Kocher, Thomas D., Jordan, Rebecca C., Lowe, Ellis R., Carleton, Karen L.   +5 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

High-Quality Genome Assemblies of 4 Members of the Podospora anserina Species Complex

The filamentous fungus Podospora anserina is a model organism used extensively in the study of molecular biology, senescence, prion biology, meiotic drive, mating-type chromosome evolution, and plant biomass degradation.
Giraud, Tatiana, Gautier, Valerie,, Hartmann, Fanny E., Johannesson, Hanna,, Ament-Velasquez, S. Lorena, Johannesson, Hanna, Silar, Philippe,, Vogan, Aaron A., Vogan, Aaron, A, Ament-Velásquez, S, Lorena, Ament-Velásquez, Sandra Lorena,, Vogan, Aaron A.,, Ament-Velasquez, S. Lorena,, Giraud, Tatiana,, Hartmann, Fanny E.,, Hartmann, Fanny, E, Wallerman, Ola,, Gautier, Valerie, Silar, Philippe, Wallerman, Ola   +19 more
core   +1 more source

Molecular Phylogeny, Classification and Evolution of Conopeptides

, 2012
Conopeptides are toxins expressed in the venom duct of cone snails (Conoidea, Conus). These are mostly well-structured peptides and mini-proteins with high potency and selectivity for a broad range of cellular targets.
Puillandre, N., Koua, Dominique Kadio, Stöcklin, R., Favreau, P., Olivera, B. M.   +4 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Molecular Phylogeny and Evolution of Dogwoods

, 2004
Dogwoods consist of morphologically diverse plants, and taxonomic circumscription and phylogenetic relationships of dogwoods have long been controversial.
Fan, Chuanzhu
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Molecular approaches to the study of ecdysozoan evolution [PDF]

, 2010
The Ecdysozoa is a large clade of animals comprising the vast majority of living species and some of the most studied invertebrate models, including fruitflies and nematodes.
Rota Stabelli, O.
core