Results 111 to 120 of about 6,342,096 (314)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Molecular Evolution of Hepatitis Viruses

Intervirology, 1999
Methods and models for analytical and quantitative researches on the evolution of hepatitis viruses using nucleotide sequences and amino acids of hepatitis viruses are described. Methods for the calculation of evolutionary rates and the construction of molecular evolutionary trees, especially by estimating the number of nucleotide substitutions and the
MIZOKAMI, Masashi, ORITO, Etsuro
openaire   +3 more sources

Genetic Mechanism of Non-Targeted-Site Resistance to Diquat in Spirodela polyrhiza

Plants
Understanding non-target-site resistance (NTSR) to herbicides represents a pressing challenge as NTSR is widespread in many weeds. Using giant duckweed (Spirodela polyrhiza) as a model, we systematically investigated genetic and molecular mechanisms of ...
Martin Höfer, Martin Schäfer, Yangzi Wang, Samuel Wink, Shuqing Xu   +4 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Evolution and biogeography of gymnosperms

, 2014
Living gymnosperms comprise only a little more than 1000 species, but represent four of the five main lineages of seed plants, including cycads, ginkgos, gnetophytes and conifers.
Ran, Jin-Hua, Jin-Hua Ran, Wang, Xiao-Quan, Xiao-Quan Wang   +3 more
core   +1 more source

Molecular Biology and Evolution of Cancer: From Discovery to Action. [PDF]

, 2019
Cancer progression is an evolutionary process. During this process, evolving cancer cell populations encounter restrictive ecological niches within the body, such as the primary tumor, circulatory system, and diverse metastatic sites.
Li, Sheng, Fisk, JN, Townsend, Jeffrey P, Cannataro, Vincent L, Ella F Gunady, Sudhir Kumar, Boddy, AM, Gaffney, Stephen G, Jeffrey P Townsend, Vincent L Cannataro, Norman A Johnson, Anna R Panchenko, Cannataro, VL, Gunady, EF, Megquier, Kate, Ciccarelli, Francesca D, Gaffney, SG, Townsend, JP, Dornburg, Alex, Somarelli, JA, Fisk, J Nicholas, Stephen G Gaffney, Fisk, Jeffrey Nicholas, Alex Dornburg, Kumar, Sudhir, Chuang, Jeffrey, Megquier, K, Panchenko, AR, Jason A Somarelli, Johnson, NA, Panchenko, Anna R, Degregori, J, Francesca D Ciccarelli, Gardner, Heather, Chuang, JH, Kate Megquier, Amy M Boddy, Gunady, Ella F, Johnson, Norman A, Heather Gardner, Kumar, Sudhir|, Dornburg, A, Sheng Li, Ciccarelli, FD, Kumar, S, DeGregori, James, Somarelli, Jason A, Jeffrey Nicholas Fisk, James DeGregori, Li, S, Boddy, Amy M, Jeffrey H Chuang, Chuang, Jeffrey H, Gardner, H   +53 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Gene Regulation and Species-Specific Evolution of Free Flight Odor Tracking in Drosophila

, 2018
The flying ability of insects has coevolved with the development of organs necessary to take-off from the ground, generate, and modulate lift during flight in complex environments.
Houot, Benjamin,, Sveriges lantbruksuniversitet.   +1 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source