Results 101 to 110 of about 6,342,096 (314)

Molecular evolution and structure of α-actinin

, 2004
The N-terminal actin-binding domain of -actinin is connected to the C-terminal EF-hands by a rod domain. Because of its ability to form dimers, -actinin can cross-link actin filaments in muscle cells as well as in nonmuscle cells.
Backman, Lars,, Virel, Ana,
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Molecular footprints of the Holocene retreat of dwarf birch in Britain [PDF]

, 2014
© 2014 The Authors. Molecular Ecology Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original ...
Bodles, WJA, Borrell, JS, Kuttapitiya, A, Richard A. Nichols, Wang, N, Nian Wang, William J A. Bodles, Anasuya Kuttapitiya, Richard J A. Buggs, Buggs, RJA, James S. Borrell, Nichols, RA   +11 more
core   +1 more source

Gene expression atlas of the Colorado potato beetle (Leptinotarsa decemlineata)

Scientific Data
The Colorado potato beetle (CPB) is a major pest of potato crops, known for its remarkable ability to develop resistance to more than 50 pesticides. For decades, CPB has served as a model species for studying insecticide resistance, insect physiology ...
Léonore Wilhelm, Yangzi Wang, Shuqing Xu   +2 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The evolution of the immune system of bees is defined by conservation, expansions, and losses

BMC Biology
Background Insect pollinators, such as bees, provide essential ecosystem services yet face increasing environmental challenges, including pathogens, which can negatively impact host fitness.
Hongfei Xu, Ina Köhler, Thomas J. Colgan   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Mechanisms of molecular evolution

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2000
Both drift and selection are important for nucleotide substitutions in evolution. The nearly neutral theory was developed to clarify the effects of these processes. In this article, the nearly neutral theory is presented with special reference to the nature of weak selection.
openaire   +3 more sources

Population genomics and epigenomics of Spirodela polyrhiza provide insights into the evolution of facultative asexuality

Communications Biology
Many plants are facultatively asexual, balancing short-term benefits with long-term costs of asexuality. During range expansion, natural selection likely influences the genetic controls of asexuality in these organisms.
Yangzi Wang, Pablo Duchen, Alexandra Chávez, K. Sowjanya Sree, Klaus J. Appenroth, Hai Zhao, Martin Höfer, Meret Huber, Shuqing Xu   +8 more
doaj   +1 more source

Morphology Evolution, Molecular Simulation, Electrical Properties, and Rheology of Carbon Nanotube/Polypropylene/Polystyrene Blend Nanocomposites: Effect of Molecular Interaction between Styrene-Butadiene Block Copolymer and Carbon Nanotube. [PDF]

Polymers (Basel), 2021
Otero Navas I, Kamkar M, Arjmand M, Sundararaj U.   +3 more
europepmc   +1 more source