Results 31 to 40 of about 2,325,018 (299)

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Enzyme-assisted high throughput sequencing of an expanded genetic alphabet at single base resolution

Nature Communications
With just four building blocks, low sequence information density, few functional groups, poor control over folding, and difficulties in forming compact folds, natural DNA and RNA have been disappointing platforms from which to evolve receptors, ligands ...
Bang Wang, Kevin M. Bradley, Myong-Jung Kim, Roberto Laos, Cen Chen, Dietlind L. Gerloff, Luran Manfio, Zunyi Yang, Steven A. Benner   +8 more
doaj   +1 more source

Prebiotic competition and evolution in self-replicating polynucleotides can explain the properties of DNA/RNA in modern living systems

BMC Evolutionary Biology, 2020
Background We hypothesize prebiotic evolution of self-replicating macro-molecules (Alberts, Molecular biology of the cell, 2015; Orgel, Crit Rev Biochem Mol Biol 39:99-123, 2004; Hud, Nat Commun 9:5171) favoured the constituent nucleotides and ...
Hemachander Subramanian, Joel Brown, Robert Gatenby   +2 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Egalitarian cooperation linked to central oxytocin levels in communal breeding house mice

Communications Biology
Relationships between adult females are fundamental to understanding diversity in animal social systems. While cooperative relationships between kin are known to promote fitness benefits, the proximate mechanisms underlying this are not well understood ...
Stefan Fischer, Callum Duffield, William T. Swaney, Rhiannon L. Bolton, Amanda J. Davidson, Jane L. Hurst, Paula Stockley   +6 more
doaj   +1 more source

aristaless1 has a dual role in appendage formation and wing color specification during butterfly development

BMC Biology, 2023
Background Highly diverse butterfly wing patterns have emerged as a powerful system for understanding the genetic basis of phenotypic variation. While the genetic basis of this pattern variation is being clarified, the precise developmental pathways ...
Erick X. Bayala, Nicholas VanKuren, Darli Massardo, Marcus R. Kronforst   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The relationship between diet, plasma glucose, and cancer prevalence across vertebrates

Nature Communications
Birds have higher plasma glucose concentrations but lower cancer prevalence than other vertebrates. However, this inverse relationship between glucose and cancer may not hold within vertebrate groups.
Stefania E. Kapsetaki, Anthony J. Basile, Zachary T. Compton, Shawn M. Rupp, Elizabeth G. Duke, Amy M. Boddy, Tara M. Harrison, Karen L. Sweazea, Carlo C. Maley   +8 more
doaj   +1 more source

The Evolution of Holmes, Holmes and Evolution [PDF]

California Law Review, 1984
The occasion of these remarks is the one-hundredth anniversary of the publication of Holmes' The Common Law, but it is not so much his book as it is his later career that explains why we observe the occasion. The Common Law is a widely known book but one more widely known than read, while perhaps it is more often read than understood.
openaire   +1 more source