Results 61 to 70 of about 10,682,507 (345)
Black hole formation and evaporation is studied in the semiclassical approximation in simple 1+1-dimensional models, with emphasis on issues related to Hawking's information paradox.
Thorlacius, Larus
core +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac+3 more
wiley +1 more source
Background Social insects vary widely in social organization, yet the genetical and ecological factors influencing this variation remain poorly known. In particular, whether spatially varying selection influences the maintenance of social polymorphisms ...
Sacha Zahnd+4 more
doaj +1 more source
Gauss-Bonnet Cosmology Unifying Late and Early-time Acceleration Eras with Intermediate Eras
In this paper we demonstrate that with vacuum $F(G)$ gravity it is possible to describe the unification of late and early-time acceleration eras with the radiation and matter domination era.
Oikonomou, V. K.
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Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Low-cost anti-mycobacterial drug discovery using engineered E. coli
Whole-cell screening for Mycobacterium tuberculosis inhibitors is complicated by the pathogen’s slow growth and biocontainment requirements. Here the authors develop engineered E.
Nadine Bongaerts+9 more
doaj +1 more source
Prebiotic Synthesis of Aspartate Using Life’s Metabolism as a Guide
A protometabolic approach to the origins of life assumes that the conserved biochemistry of metabolism has direct continuity with prebiotic chemistry. One of the most important amino acids in modern biology is aspartic acid, serving as a nodal metabolite
Stuart A. Harrison+3 more
doaj +1 more source
Galapagos evolution continues [PDF]
Summary of symposium "Evolution in the Galapagos" held December 8, 1982 in ...
Boag, Peter T.
core
Nonequilibrium evolution thermodynamics
A new approach - nonequilibrium evolution thermodynamics, is compared with classical variant of Landau approachComment: 4 pages, 1 ...
A. S. Steinberg+8 more
core +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source