Results 41 to 50 of about 218,478 (262)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

On modelling wave motion in microstructured solids; pp. 241–246 [PDF]

open access: yesProceedings of the Estonian Academy of Sciences, 2009
The Mindlin-type model is used for describing the longitudinal deformation waves in microstructured solids. The evolution equation (one-wave equation) is derived for the hierarchical governing equation (two-wave equation) in the nonlinear case using the ...
Merle Randrüüt   +2 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Almost automorphic mild solutions of hyperbolic evolution equations with stepanov-like almost automorphic forcing term

open access: yesElectronic Journal of Differential Equations, 2012
This article concerns the existence and uniqueness of almost automorphic solutions to the semilinear parabolic boundary differential equations $$displaylines{ x'(t)=A_mx(t)+f(t,x(t)), quad tin mathbb{R}, cr Lx(t)=phi(t,x(t)), quad tin mathbb{R}, }$$
Indira Mishra, Dhirendra Bahuguna
doaj  

Parallel solution methods and preconditioners for evolution equations

open access: yesMathematical Modelling and Analysis, 2018
The recent development of the high performance computer platforms shows a clear trend towards heterogeneity and hierarchy. In order to utilize the computational power, particular attention must be paid to finding new algorithms or adjust existing ones so ...
Owe Axelsson   +2 more
doaj   +1 more source

Finite-approximate controllability of Hilfer fractional evolution equations of Sobolev type with nonlocal conditions

open access: yes上海师范大学学报. 自然科学版, 2020
We discuss the finite-approximate controllability of Hilfer fractional evolution equations of Sobolev type with nonlocal conditions in Hilbert spaces.With the assumption that the corresponding linear system is approximately controllable,we obtain ...
WANG Xingzhao   +3 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Nonlinear second order evolution equations with state-dependent delays

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 2012
We consider second order quasilinear parabolic equations where also the main part contains functional dependence and state-dependent delay on the unknown function. Existence and some qualitative properties of the solutions are shown.
László Simon
doaj   +1 more source

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