Results 41 to 50 of about 218,478 (262)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
On modelling wave motion in microstructured solids; pp. 241–246 [PDF]
The Mindlin-type model is used for describing the longitudinal deformation waves in microstructured solids. The evolution equation (one-wave equation) is derived for the hierarchical governing equation (two-wave equation) in the nonlinear case using the ...
Merle Randrüüt +2 more
doaj +1 more source
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
This article concerns the existence and uniqueness of almost automorphic solutions to the semilinear parabolic boundary differential equations $$displaylines{ x'(t)=A_mx(t)+f(t,x(t)), quad tin mathbb{R}, cr Lx(t)=phi(t,x(t)), quad tin mathbb{R}, }$$
Indira Mishra, Dhirendra Bahuguna
doaj
Parallel solution methods and preconditioners for evolution equations
The recent development of the high performance computer platforms shows a clear trend towards heterogeneity and hierarchy. In order to utilize the computational power, particular attention must be paid to finding new algorithms or adjust existing ones so ...
Owe Axelsson +2 more
doaj +1 more source
We discuss the finite-approximate controllability of Hilfer fractional evolution equations of Sobolev type with nonlocal conditions in Hilbert spaces.With the assumption that the corresponding linear system is approximately controllable,we obtain ...
WANG Xingzhao +3 more
doaj +1 more source
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Nonlinear second order evolution equations with state-dependent delays
We consider second order quasilinear parabolic equations where also the main part contains functional dependence and state-dependent delay on the unknown function. Existence and some qualitative properties of the solutions are shown.
László Simon
doaj +1 more source

