Results 131 to 140 of about 1,625,637 (295)

BV Solutions to Evolution Inclusion with a Time and Space Dependent Maximal Monotone Operator

Mathematics
This paper deals with the research of solutions of bounded variation (BV) to evolution inclusion coupled with a time and state dependent maximal monotone operator. Different problems are studied: existence of solutions, unicity of the solution, existence
Charles Castaing, Christiane Godet-Thobie, Manuel D. P. Monteiro Marques   +2 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Hydrothermal Fluid evolution in the Dalli porphyry Cu-Au Deposit: Fluid Inclusion microthermometry studies

Journal of Economic Geology, 2015
Introduction A wide variety of world-class porphyry Cu deposits occur in the Urumieh-Dohktar magmatic arc (UDMA) of Iran.The arc is composed of calc-alkaline granitoid rocks, and the ore-hosting porphyry intrusions are dominantly granodiorite to quartz ...
Alireza Zarasvandi, Fateme Asadi, Houshang Pourkaseb, Farhad Ahmadnejad, Hasan Zamanian   +4 more
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Aging in the Digital Tsunami: Older Micro-Influencers, Digital Inclusion, and Dynamic Access on Douyin

Social Media + Society
As China undergoes rapid demographic aging, older Wanghong (influencers over 60) on platforms like Douyin challenge traditional digital inclusion frameworks that conceptualize access as linear progression through motivational, material, skills, and usage
Yingwen Wang, Yanghui Cao
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Existence of mild solutions of a semilinear evolution differential inclusions with nonlocal conditions

Electronic Journal of Differential Equations, 2009
In this paper we prove the existence of a mild solution for a semilinear evolution differential inclusion with nonlocal condition and governed by a family of linear operators, not necessarily bounded or closed, in a Banach space.
Reem A. Al-Omair, Ahmed G. Ibrahim
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source