Results 121 to 130 of about 4,368,379 (347)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Formation of Multi-Type Inclusions during the Cooling and Solidification of Steel: A Trend Model

Metals, 2018
This paper presents a trend model of the competitive formation of multi-type inclusions during the cooling and solidification of steel. The model is able to predict the evolution of various inclusions, including their type, composition and size ...
Dali You, Susanne K. Michelic, Christian Bernhard   +2 more
doaj   +1 more source

Endolithic colonization of fluid inclusion trails in mineral grains [PDF]

, 2005
Many scenarios for the colonization of planetary surfaces by microbial life involve endoliths.
Baron, M., Cockell, C. S., Parnell, J.
core  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Variational Analysis of Evolution Inclusions

SIAM Journal on Optimization, 2007
The paper is devoted to optimization problems of the Bolza and Mayer types for evolution systems governed by nonconvex Lipschitzian differential inclusions in Banach spaces under endpoint constraints described by finitely many equalities and inequalities with generally nonsmooth functions. We develop a variational analysis of such problems mainly based
openaire   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The Evolution Analysis and Removal of Oxide Inclusion in Tire Cord Steel XLX72 A [PDF]

Teshugang
 Aiming at the problem of inclusions evolution control and removal of fine wire cord steel of 0.175 mm and below specifications， the transition control and removal of inclusions in cord steel were studied by using the technology of Si-Mn deoxidation，
Yang Jianhua, Ju Yinjun, Yang Jun
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Effect of MgO content in refining slag on the non-metallic inclusions in tire cord steel

Journal of Materials Research and Technology
In order to weaken the corrosion of refractory during the refining process of tire cord steel, the MgO content in the low basicity (w(CaO)/w(SiO2)≈1.0) slags was increased from 7.9% to 12.6% in industrial experiments.
Guodong Song, Zhiyin Deng, Fengting Qin, Zonghui Liu, Miaoyong Zhu   +4 more
doaj   +1 more source