Results 71 to 80 of about 186,910 (306)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

FEATURE SALTATION AND THE EVOLUTION OF MIMICRY

, 2011
In Batesian mimicry, a harmless prey species imitates the warning coloration of an unpalatable model species. A traditional suggestion is that mimicry evolves in a two-step process, in which a large mutation first achieves approximate similarity to the ...
Olof Leimar, Gabriella Gamberale-Stille, Balogh, Alexandra C. V.,, Birgitta S. Tullberg, Alexandra C. V. Balogh, Gamberale-Stille, Gabriella,, Tullberg, Birgitta S.,, Leimar, Olof,   +7 more
core   +1 more source

Inferring the physics of protoplanetary disc evolution from the irradiated Cygnus OB2 region

Astronomy & Astrophysics
Context. Determining the physical processes driving protoplanetary disc evolution is of paramount importance for understanding planet formation. Our current understanding has crystallised around two possible evolution scenarios: turbulent viscosity and ...
Weder Jesse, Winter Andrew J., Mordasini Christoph   +2 more
doaj   +1 more source

Extended Flow-Based Security Assessment for Real-Sized Transmission Network Planning

Energies, 2020
The evolution of electric power systems involves several aspects, dealing with policy and economics as well as security issues. Moreover, due to the high variability of operating conditions, evolution scenarios have to be carefully defined.
Maria Dicorato, Michele Trovato, Chiara Vergine, Corrado Gadaleta, Benedetto Aluisio, Giuseppe Forte   +5 more
doaj   +1 more source

Using an age-structured COVID-19 epidemic model and data to model virulence evolution in Wuhan, China

Journal of Biological Dynamics, 2022
COVID-19 is a disease caused by infection with the virus 2019-nCoV, a single-stranded RNA virus. During the infection and transmission processes, the virus evolves and mutates rapidly, though the disease has been quickly controlled in Wuhan by ‘Fangcang’
Xi-Chao Duan, Xue-Zhi Li, Maia Martcheva, Sanling Yuan   +3 more
doaj   +1 more source

Representing scenarios for process evolution management

CoRR, 2018
In the following writing we discuss a conceptual framework for representing events and scenarios from the perspective of a novel form of causal analysis. This causal analysis is applied to the events and scenarios so as to determine measures that could be used to manage the development of the processes that they are a part of in real time.
openaire   +2 more sources

Visualizing alternative scenarios of evolution in heritage architecture [PDF]

Proceedings of the 11th International Conference on Knowledge Management and Knowledge Technologies, 2011
Our objective is to support reasoning tasks in heritage architecture with graphics enabling analysts to visualise and share their understanding of how, from a given set of information, alternative scenarios or evolution can be inferred. The paper comments on the nature of the cognitive processes in historical sciences, and on factors that need to be ...
Dudek, Iwona, Blaise, Jean-Yves
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

How Will Hydroelectric Power Generation Develop under Climate Change Scenarios? [PDF]

, 2011
Climate change has a large impact on water resources and thus on hydropower. Hydroelectric power generation is closely linked to the regional hydrological situation of a watershed and reacts sensitively to changes in water quantity and seasonality.
Bach, Heike, Mauser, Wolfram, Markus Weber, Prasch, Monika, Heike Bach, Koch, Franziska, Weber, Markus, Monika Prasch, Appel, Florian, Franziska Koch, Florian Appel, Wolfram Mauser   +11 more
core   +1 more source

Scenarios planning: the evolution of prospective thinking

Revista de Ciências da Administração : RCA, 2005
The world is changing even more than before. Around the world, the organizational stability is in face of threats unnoticed before, due to technologic innovations, uncontrolled financial markets, up to date customers, and an observant society and ...
Maurício Fernandes Pereira, Gilberto de Oliveira Moritz   +1 more
doaj