Results 81 to 90 of about 985,031 (290)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Generalized Holographic Cosmology

, 2012
We consider general black hole solutions in five-dimensional spacetime in the presence of a negative cosmological constant. We obtain a cosmological evolution via the gravity/gauge theory duality (holography) by defining appropriate boundary conditions ...
Anurag Sahay, Apostolopoulos P S, Ashtekar A, Banerjee S, Compere G, de Haro S, George Siopsis, Henneaux M, Hovdebo J L, Kiritsis E, Kiritsis E, Kraus P, Maldacena J M, Petkou A C, Samrat Bhowmick, Souvik Banerjee, Witten E   +16 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Big rip avoidance via black holes production

, 2009
We consider a cosmological scenario in which the expansion of the Universe is dominated by phantom dark energy and black holes which condense out of the latter component.
D. Gross, D. N. Page, D. Pavón, D. Pavón, G. Sansone, J. A. Jiménez Madrid, J. C. Fabris, J. D. Barrow, J. I. Kapusta, P. J. E. Peebles, R. R. Caldwell, S. W. Hawking, T. Piran   +12 more
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Nonlinear self-interaction of plane gravitational waves

, 2003
Recently Mendonca and Cardoso [Phys. Rev. D, vol. 66, 104009 (2002)] considered nonlinear gravitational wave packets propagating in flat space-time. They concluded that the evolution equation - to third order in amplitude - takes a similar form to what ...
Brodin, G., Cardoso, V., Marklund, M., Mendonca, J. T., Servin, M.   +4 more
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Modeling The Large Scale Bias of Neutral Hydrogen

, 2010
We present new analytical estimates of the large scale bias of neutral hydrogen (HI). We use a simple, non-parametric model which monotonically relates the total mass of a halo M_tot with its HI mass M_HI at zero redshift; for earlier times we assume ...
Alberto Vallinotto, Ansari, Bagla, Barkana, Berlind, Blake, Colín, Conroy, Conroy, Eisenstein, Eisenstein, Felipe A. Marín, Gnedin, Hee-Jong Seo, Hu, Kravtsov, Kravtsov, Marín, Nagai, Nickolay Y. Gnedin, Obreschkow, Prochaska, Prochaska, Rao, Scoccimarro, Seo, Seo, Tinker, Visbal, Volonteri, Wyithe, Zwaan   +31 more
core   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source