Results 101 to 110 of about 2,229,434 (295)

Trust Region Evolution Strategies

open access: yesProceedings of the AAAI Conference on Artificial Intelligence, 2019
Evolution Strategies (ES), a class of black-box optimization algorithms, has recently been demonstrated to be a viable alternative to popular MDP-based RL techniques such as Qlearning and Policy Gradients. ES achieves fairly good performance on challenging reinforcement learning problems and is easier to scale in a distributed setting.
Guoqing Liu   +6 more
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Applying Evolution Strategies for Chest Radiographs Segmentation [PDF]

open access: yesComputer Science Journal of Moldova, 2006
WSegmentation is one of the key areas in computer vision. Advanced techniques, such as active contour models and active shape models suffer from many drawbacks. An improvement of the two approaches, based in evolution strategies, is presented.
Oliviu Matei
doaj  

The diplomat's dilemma: Maximal power for minimal effort in social networks

open access: yes, 2008
Closeness is a global measure of centrality in networks, and a proxy for how influential actors are in social networks. In most network models, and many empirical networks, closeness is strongly correlated with degree.
A Barrat   +26 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

How to Ensure System Sustainability: Paradoxical Cognition and Adaptive Strategies for the Value Creation Process of Megaprojects

open access: yesSystems
A megaproject is a complex technological-social-natural system, and its “double-edged sword” effect raises significant attention in research on system sustainability.
Faping Shui   +4 more
doaj   +1 more source

Reaction-Diffusion Processes on Interconnected Scale-Free Networks

open access: yes, 2014
We study the two particle annihilation reaction $A+B\rightarrow \emptyset$ on interconnected scale free networks, using different interconnecting strategies. We explore how the mixing of particles and the process evolution are influenced by the number of
Garas, Antonios
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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