Results 61 to 70 of about 880,221 (312)

Anaerobic thiosulfate oxidation by the Roseobacter group is prevalent in marine biofilms

Nature Communications, 2023
Thiosulfate oxidation by microbes has a major impact on global sulfur cycling. Here, we provide evidence that bacteria within various Roseobacter lineages are important for thiosulfate oxidation in marine biofilms.
Wei Ding, Shougang Wang, Peng Qin, Shen Fan, Xiaoyan Su, Peiyan Cai, Jie Lu, Han Cui, Meng Wang, Yi Shu, Yongming Wang, Hui-Hui Fu, Yu-Zhong Zhang, Yong-Xin Li, Weipeng Zhang   +14 more
doaj   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Large language models recover scientific collaboration networks from text

Applied Network Science
Science is a collaborative endeavor. Yet, unlike co-authorship, interactions within and across teams are seldom reported in a structured way, making them hard to study at scale.
Rathin Jeyaram, Robert N Ward, Marc Santolini   +2 more
doaj   +1 more source

Crp and Arc system directly regulate the transcription of NADH dehydrogenase genes in Shewanella oneidensis nitrate and nitrite respiration

Microbiology Spectrum
NADH oxidation by NADH dehydrogenases (NDHs) is crucial for feeding respiratory quinone pool and maintaining the balance of NADH/NAD+. In the respiratory model organism Shewanella oneidensis, which possesses four NDHs, the longstanding notion had been ...
Jia-Rong Liu, Zhi-Qing Wang, Fei-Fei Li, Zhen-Kun Li, Ming-Chen Wang, Na Wang, Yu An, Xiu-Lan Chen, Yu-Zhong Zhang, Hui-Hui Fu   +9 more
doaj   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Healthy and moribund Zhikong scallops (Chlamys farreri) developed different viral communities during a mass mortality event

mSystems
Viral assemblages of scallops are still relatively unknown. Here, metagenomic analysis was used to study virus communities in the gut of scallops to establish the first scallop virome data set (SVD); this contains 7,447 viral operational taxonomic units.
Jiaxiang Li, Kaiyang Zheng, Wei Ding, Longfei Lu, Yantao Liang, Yao Xiong, Zhongcheng Wei, Chen Gao, Yue Su, Ziyue Wang, Xin Chen, Zhenmin Bao, Xiaoli Hu, Andrew McMinn, Min Wang   +14 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Dynamics of System Evolution [PDF]

, 2012
A system is built to serve a common purpose of an organization or a network; it usually consists of a set of operations, interfaces for inputs and outputs, and a group of users with direct or indirect interactions. Systems exist in nature as well as in virtually any conceivable area of human society (Dori, 2003).
Ashirul Mubin, R. Rahman, Daniel Ray
openaire   +3 more sources

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source