Results 81 to 90 of about 27,661,028 (295)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Mechanistic insights into the dimethylsulfoniopropionate synthesis enzyme BurB

Applied and Environmental Microbiology
Dimethylsulfoniopropionate (DMSP) is one of the most abundant organosulfur molecules on Earth. It possesses various physiological functions in microorganisms and plays key roles in the global climate regulation.
Nan Zhang, Yue Lin, Ning Wang, Hai-Yan Cao, Buke Zhang, Ya-Nan Gao, Yu-Zhong Zhang, Chun-Yang Li   +7 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

A synthetic RNA-mediated evolution system in yeast. [PDF]

Nucleic Acids Res, 2021
Jensen ED, Laloux M, Lehka BJ, Pedersen LE, Jakočiūnas T, Jensen MK, Keasling JD.   +6 more
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural and molecular basis for phosphate recognition by SAR11 bacteria

mBio
Phosphorus is a critical limiting nutrient that constrains the survival, growth, and reproduction of marine microorganisms in nutrient-limited ecosystems.
Wen-Jing Zhu, Chen Wang, Li Liu, Jian-Xun Li, Hou-Qi Wang, Meng-Qi Wang, Hai-Yan Cao, Xiu-Lan Chen, Qi-Long Qin, Yu-Zhong Zhang, Mei-Ling Sun, Peng Wang   +11 more
doaj   +1 more source

EASINESS: E. coli Assisted Speedy affINity-maturation Evolution SyStem. [PDF]

Front Immunol, 2021
Zhang HN, Xue JB, Wang AZ, Jiang HW, Merugu SB, Li DW, Tao SC.   +6 more
europepmc   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Community organization and network complexity and stability: contrasting strategies of prokaryotic versus eukaryotic microbiomes in the Bohai Sea and Yellow Sea

mSphere
Unraveling the effects of spatial gradients on microbiome assembly and association is a challenging topic that remains understudied in the coastal ecosystem.
Xiaoxiao Wang, Hualong Wang, Yantao Liang, Andrew McMinn, Min Wang   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source