Results 101 to 110 of about 4,705,313 (296)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Diversity and Ecological Roles of Deep-Sea Viruses

Ocean-Land-Atmosphere Research
The deep sea is one of the least-explored ecosystems on Earth. Deep-sea virus communities are crucial components of this ecosystem and play crucial roles in food webs and biogeochemical cycles.
Ying Han, Chen Gao, Yantao Liang, Andrew McMinn, Min Wang   +4 more
doaj   +1 more source

Application of a bacterial experimental evolution system to visualize and teach evolution in action: A course-based undergraduate research experience. [PDF]

CourseSource, 2022
Kessler C, Mazza W, Christopher K, Kim W.   +3 more
europepmc   +1 more source

Concept Evolution in Information System Evolution [PDF]

, 2004
Contains fulltext : 60241.pdf (author's version ) (Open Access)
Proper, H.A., Hoppenbrouwers, S.J.B.A.
openaire  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A novel grey prediction model with a feedforward neural network based on a carbon emission dynamic evolution system and its application. [PDF]

Environ Sci Pollut Res Int, 2023
Nie W, Ao O, Duan H.
europepmc   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A new Early Jurassic dinosaur represents the earliest-diverging and oldest sauropodomorph of East Asia

Scientific Reports
A new dinosaur assemblage from the Lower Jurassic at Wande Town, Wuding County, Yunnan Province, China is discovered recently. Here a new sauropodomorph from this site, Wudingloong wui gen. et sp.
Ya-Ming Wang, Qian-Nan Zhang, Yan-Chao Wang, Huan Xu, Jianbo Chen, Zhuo Feng, Xing Xu, Tao Wang, Hai-Lu You   +8 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Vibrio cyclitrophicus phage encoding gene transfer agent fragment, representing a novel viral family

Virus Research
Vibrio is a prevalent bacterial genus in aquatic environments and exhibits diverse metabolic capabilities, playing a vital role in marine biogeochemical cycles. This study isolated a novel virus infecting Vibrio cyclitrophicus, vB_VviC_ZQ26, from coastal
Yao Xiong, Keran Ma, Xiao Zou, Yantao Liang, Kaiyang Zheng, Tiancong Wang, Hong Zhang, Yue Dong, Ziyue Wang, Yundan Liu, Hongbing Shao, Andrew McMinn, Min Wang   +12 more
doaj   +1 more source