Results 41 to 50 of about 3,008,864 (289)
A Customized Differential Evolutionary Algorithm for Bounded Constrained Optimization Problems
Complexity, 2021 Bound-constrained optimization has wide applications in science and engineering. In the last two decades, various evolutionary algorithms (EAs) were developed under the umbrella of evolutionary computation for solving various bound-constrained benchmark ...
Wali Khan Mashwani +4 more
doaj +1 more source
Personalized-Template-Guided Intelligent Evolutionary Algorithm
Applied SciencesExisting heuristic algorithms are based on inspiration sources and have not yet done a good job of basing themselves on optimization principles to minimize and utilize historical information, which may lead to low efficiency, accuracy, and stability of ...
Dongni Hu +4 more
doaj +1 more source
Hybridization of Evolutionary Algorithms [PDF]
, 2011 Evolutionary algorithms are good general problem solver but suffer from a lack of domain specific knowledge. However, the problem specific knowledge can be added to evolutionary algorithms by hybridizing. Interestingly, all the elements of the evolutionary algorithms can be hybridized.
Fister, Iztok +2 more
openaire +3 more sources
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Evolutionary Synthesis of HVAC System Configurations: Algorithm Development. [PDF]
, 2008 This paper describes the development of an optimization procedure for the synthesis of novel heating, ventilating, and air-conditioning (HVAC) system configurations. Novel HVAC system designs can be synthesized using model-based optimization methods. The
Angelov, Plamen +4 more
core +5 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Orbit Transfer Manoeuvres as a Test Benchmark for Comparison Metrics of Evolutionary Algorithms [PDF]
, 2009 In the present paper some metrics for evaluating the performance of evolutionary algorithms are considered. The capabilities of two different optimisation approaches are compared on three test cases, represented by the optimisation of orbital transfer ...
G. Avanzini +6 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source