Results 91 to 100 of about 578,372 (311)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Supplementary Tables 3-6 from Molecular Evolutionary Analysis of Cancer Cell Lines
, 2010 Supplementary Tables 3-6 from Molecular Evolutionary Analysis of Cancer Cell ...
Kurt R. Auger (449760) +8 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Supplementary Figure 1 from Molecular Evolutionary Analysis of Cancer Cell Lines
, 2010 Supplementary Figure 1 from Molecular Evolutionary Analysis of Cancer Cell ...
Kurt R. Auger (449760) +8 more
core +1 more source
, 2023 S1 Graphical abstract - SARS-CoV-2 protein structure and sequence mutations: Evolutionary analysis and effects on virus ...
Ugo Lomoio (16624608) +4 more
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
BEAST2: Bayesian evolutionary analysis sampling trees
, 2014 BEAST (Bayesian evolutionary analysis sampling trees) is package for evolutionary inference from molecular sequences.https://github.com/CompEvol ...
Suchard, M +5 more
core
Supplementary Figure 2 from Molecular Evolutionary Analysis of Cancer Cell Lines
, 2010 Supplementary Figure 2 from Molecular Evolutionary Analysis of Cancer Cell ...
Kurt R. Auger (449760) +8 more
core +1 more source