Results 111 to 120 of about 578,372 (311)

Supplementary Table 1 from Molecular Evolutionary Analysis of Cancer Cell Lines

, 2010
Supplementary Table 1 from Molecular Evolutionary Analysis of Cancer Cell ...
Kurt R. Auger (449760), Yan Zhang (8098), Wendy S. Halsey (15011549), Michael J. Italia (15040560), Stephanie F. Van Horn (15040563), Ganesh M. Sathe (14892279), Michal Magid-Slav (178538), Joanna D. Holbrook (7361606), James R. Brown (178534)   +8 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Supplementary - Evolutionary analysis of p38 stress activated kinases in unicellular relatives of animals suggests an ancestral function in osmotic stress

, 2022
The item contains Supplementary Files 1-4 for the manuscript "Evolutionary analysis of p38 stress activated kinases in unicellular relatives of animals suggest an ancestral function in osmotic stress"
Multicellgenome Lab (2628379)
core   +1 more source

Editorial: Computational predictions, dynamic tracking, and evolutionary analysis of antibiotic resistance through the mining of microbial genomes and metagenomic data, volume II

Frontiers in Microbiology, 2023
Qi Zhao, Jian Li, Alfred Tay, Liang Wang, Liang Wang   +4 more
doaj   +1 more source

Mayaro virus infection, the next epidemic wave after Zika? Evolutionary and structural analysis

Asian Pacific Journal of Tropical Medicine, 2018
Objective: To evaluate the evolution of the pathogen Mayaro virus, causing Mayaro fever (a mosquito-borne disease) and to perform selective pressure analysis and homology modelling.
Eleonora Cella, Marta Giovanetti, Teresa Milano, Marta Fogolari, Francesco Garilli, Ivailo Alexiev, Riccardo Bazzardi, Marco Salemi, Luiz Carlos Junior Alcantara, Silvia Angeletti, Stefano Pascarella, Massimo Ciccozzi   +11 more
doaj   +1 more source

On the analysis of the (1+1) evolutionary algorithm

Theoretical Computer Science, 2002
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Stefan Droste, Thomas Jansen 0001, Ingo Wegener   +2 more
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Genome-wide analysis of bHLH transcription factor family reveals their involvement in kernel development and biotic stress responses in Chinese chestnut

Frontiers in Plant Science
IntroductionThe basic helix-loop-helix (bHLH) transcription factor family plays crucial roles in plant growth, development, and responses to environmental stresses.
Rongchen Li, Rongchen Li, Rongchen Li, Liyun Huang, Xiaolu Huang, Jianming Liao, Xiaojuan Wei, Junji Li, Guangyu Zeng, Zhuogong Shi, Jingzheng Zhang, Zhiheng Zhao   +11 more
doaj   +1 more source

Respite in Dementia: An Evolutionary Concept Analysis

Dementia, 2017
Aim There is a lack of conceptual clarity around ‘respite’ as it relates to people with dementia and their carers. This study provides clarification on the use and meaning of the term and considers the concept in relation to the dominant care paradigm in dementia, i.e. person-centred care.
O'Shea, Emma, Timmons, Suzanne, O'Shea, Eamon, Fox, Siobhán, Irving, Kate   +4 more
openaire   +3 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source