Results 71 to 80 of about 2,270,763 (304)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Ernst Mayr and Evolutionary Biology [PDF]

Evolution, 1994
It is possible to feel such communion with the works of our scientific predecessors as to inspire not only admiration, but also gratitude and even affection. Long before I met him, Ernst Mayr had profoundly affected my development, for probably the most influential event of my graduate education had been a year-long, line-by-line exegesis, in a ...
openaire   +2 more sources

Testing Wallace's intuition: water type, reproductive isolation and divergence in an Amazonian fish

, 2018
Alfred Russel Wallace proposed classifying Amazon rivers based on their colour and clarity: white, black and clear water. Wallace also proposed that black waters could mediate diversification and yield distinct fish species.
Powell, Daniel L., Farias, Izeni P., Pires, Tiago H. S., Borghezan, Elio A., Ropke, Cristhiana P., Machado, Valéria Nogueira, Oliveira, Claudio [UNESP], Claudio Oliveira, Tiago H. S. Pires, Cristhiana P. Röpke, Pires, Tiago H.S., Jansen Zuanon, Izeni P. Farias, Valeria N. Machado, Oliveira, Claudio, Daniel L. Powell, Machado, Valeria N., Zuanon, Jansen, Röpke, Cristhiana Paula, Elio A. Borghezan   +19 more
core   +1 more source

Chromatin remodelling and antisense-mediated up-regulation of the developmental switch gene eud-1 control predatory feeding plasticity

Nature Communications, 2016
In the nematode Pristionchus pacificus, a developmental switch, the sulfatase eud-1, controls mouth-form plasticity. Here, the authors show that mutations in two conserved histone modifying enzymes mimic the eud-1 phenotype, in part mediated by an ...
Vahan Serobyan, Hua Xiao, Suryesh Namdeo, Christian Rödelsperger, Bogdan Sieriebriennikov, Hanh Witte, Waltraud Röseler, Ralf J. Sommer   +7 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

The Queen of Problems in Evolutionary Biology

, 2019
Sexual reproduction is widespread amongst higher eukaryotes. But why are there not many more organisms reproducing asexually? After all, an asexual organism avoids making males, can thus in theory reproduce more efficiently, and one asexual mutant should
Meirmans, P.G.; id_orcid, Meirmans, S., Meirmans, P.G., Stephanie Meirmans, Patrick G Meirmans   +4 more
core   +1 more source

An evolutionary ratchet leading to loss of elongation factors in eukaryotes [PDF]

, 2014
Background The GTPase eEF1A is the eukaryotic factor responsible for the essential, universal function of aminoacyl-tRNA delivery to the ribosome.
Kamenski, Piotr, Atkinson, Gemma C.,, Atkinson, Gemma C., Soosaar, Axel, Hauryliuk, Vasili,, Ivan Chicherin, Martin Carr, Tenson, Tanel,, Vasili Hauryliuk, Carr, Martin, Tanel Tenson, Kamenski, Piotr,, Kuzmenko, Anton, Hauryliuk, Vasili, Tenson, Tanel, Kuzmenko, Anton,, Chicherin, Ivan,, Carr, Martin,, Piotr Kamenski, Gemma C Atkinson, Soosaar, Axel,, Anton Kuzmenko, Lund University., Axel Soosaar, Chicherin, Ivan   +24 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Evolutionary Biology of Chelicerata

Annual Review of Entomology
Chelicerata constitutes an ancient, biodiverse, and ecologically significant group of Arthropoda. The study of chelicerate evolution has undergone a renaissance in the past decade, resulting in major changes to our understanding of the higher-level phylogeny and internal relationships of living orders.
Prashant P, Sharma, Efrat, Gavish-Regev
openaire   +2 more sources

Evolutionary Biology Needs Wild Microbiomes

Frontiers in Microbiology, 2017
The microbiome is a vital component to the evolution of a host and much of what we know about the microbiome derives from studies on humans and captive animals.
Sarah M. Hird
doaj   +1 more source